A Judgement Bias Test to Assess Affective State and Potential Therapeutics in a Rat Model of Chemotherapy-Induced Mucositis

Scientific Reports
Rebecca P GeorgeA L Whittaker

Abstract

Chemotherapy-induced mucositis is an extremely painful condition that occurs in 40-60% of patients undergoing chemotherapy. As mucositis currently has no effective treatment, and due to the self-limiting nature of the condition, the major treatment aims are to manage symptoms and limit pain with significance placed on improving patient quality of life. Rodent models are frequently used in mucositis research. These investigations typically assess pathological outcomes, yet fail to include a measure of affective state; the key therapeutic goal. Assessment of cognitive biases is a novel approach to determining the affective state of animals. Consequently, this study aimed to validate a cognitive bias test through a judgement bias paradigm to measure affective state in a rat model of chemotherapy-induced intestinal mucositis. Rats with intestinal mucositis demonstrated a negative affective state, which was partially ameliorated by analgesic administration, whilst healthy rats showed an optimistic response. This study concluded that the judgement bias test was able to evaluate the emotional state of rats with chemotherapy-induced mucositis. These findings provide a foundation for future refinement to the experimental design associat...Continue Reading

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Citations

Mar 19, 2019·Current Opinion in Supportive and Palliative Care·Andrea M Stringer, Nicole Blijlevens
Sep 19, 2020·International Journal of Molecular Sciences·David DahlgrenHans Lennernäs
Sep 25, 2019·Animals : an Open Access Journal From MDPI·Rebecca P GeorgeAlexandra L Whittaker
Mar 7, 2021·The European Journal of Neuroscience·Sung Ching YeungChi Wai Cheung
Mar 24, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lauren C ChartierSuzanne Mashtoub
Aug 8, 2021·Animals : an Open Access Journal From MDPI·Laura MarshAlexandra L Whittaker

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