A ketogenic diet does not impair rat behavior or long-term potentiation.

Epilepsia
Liu Lin ThioKelvin A Yamada

Abstract

The effect of the ketogenic diet on behavior and cognition is unclear. We addressed this issue in rats behaviorally and electrophysiologically.We fed postnatal day 21 rats a standard diet (SD), ketogenic diet (KD), or calorie-restricted diet (CR) for 2–3 weeks. CR controlled for the slower weight gain experienced by KD-fed rats. We assessed behavioral performance with a locomotor activity and a conditioned fear test. To evaluate possible parallel effects of diet on synaptic function, we examined paired-pulse modulation (PPM) and long-term potentiation (LTP) in the medial perforant path in vivo. KD-fed rats performed similarly to SD-fed rats on the behavioral tests and electrophysiologic assays. These data suggest that the KD does not alter behavioral performance or synaptic plasticity.

References

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Apr 1, 2009·Behavioral Neuroscience·Tristan ShumanStephan G Anagnostaras

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Citations

Oct 16, 2012·Epilepsia·Katja KobowJong M Rho
May 27, 2011·Journal of Neurophysiology·Jessica L KorandaJ Harry Blaise
Feb 11, 2012·Current Opinion in Neurology·Eric H Kossoff, Adam L Hartman
Aug 23, 2011·Epilepsy Research·Liu Lin Thio
Sep 2, 2011·Epilepsy Research·S A MasinoD Boison
Aug 30, 2011·Epilepsy Research·Tove HallböökBronwen Martin
Apr 12, 2014·Journal of Lipid Research·Mayumi L Prins, Joyce H Matsumoto
Oct 19, 2017·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Arkadiusz Damian LiśkiewiczJoanna Lewin-Kowalik
Mar 9, 2019·Brain and Behavior·Jie HuangXiang-Dong Sun
Feb 15, 2019·Frontiers in Neuroscience·Isabella D'Andrea MeiraPriscila Oliveira da Conceição
Jul 19, 2020·Brain Structure & Function·Kinga GziełoZuzanna Setkowicz
May 27, 2015·Physiological Reports·J Harry BlaiseSusan A Masino
Jun 5, 2021·Brain, Behavior, and Immunity·Arkadiusz D LiśkiewiczJoanna Lewin-Kowalik

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