A ketogenic diet exerts beneficial effects on body composition of cancer patients during radiotherapy: An interim analysis of the KETOCOMP study

Journal of Traditional and Complementary Medicine
Rainer J KlementReinhart A Sweeney

Abstract

Ketogenic diets (KDs) have gained interest as a complementary treatment for cancer patients. Here we present first results of our ongoing KETOCOMP study (NCT02516501) concerning body composition changes among rectal, breast and head & neck cancer (HNC) patients who consumed a KD during curative radiotherapy (RT). Sixty-one patients eating a non-ketogenic diet were compared to 20 patients on a KD supplemented with 10 g essential amino acids on RT days. Body composition was measured prior to and weekly during RT using 8-electrode bioimpedance analysis. Longitudinal body composition data were analyzed using linear mixed effects models. Patients on the KD exhibited nutritional ketosis, defined as serum β-hydroxybutyrate levels ≥0.5 mmol/l, in a median of 69.0% of blood measurements (range 0-100%) performed in our clinic. In rectal and breast cancer patients, KD was significantly associated with a loss of 0.5 and 0.4 kg fat mass per week (p = 0.00089 and 8.49 × 10-5, respectively), with no significant changes in fat free and skeletal muscle mass. In HNC patients, concurrent chemotherapy was the strongest predictor of body weight, fat free and skeletal muscle mass loss during RT, while consuming a KD was significantly associated with...Continue Reading

Citations

Mar 28, 2020·Expert Review of Anticancer Therapy·Rainer Johannes Klement
Jan 14, 2020·Medical Oncology·Rainer J KlementReinhart A Sweeney
Apr 5, 2021·Clinical and Experimental Medicine·Maximilian RömerJutta Huebner
Jun 3, 2021·Nutrients·Kathryn Dowis, Simran Banga
Jul 8, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Rainer J KlementReinhart A Sweeney
Oct 31, 2021·Journal of Translational Medicine·Taiana Campos LeiteGiuseppe Intini
Dec 15, 2020·Complementary Medicine Research·Rainer Johannes KlementReinhart A Sweeney

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Methods Mentioned

BETA
pancreatectomy
X-ray

Clinical Trials Mentioned

NCT02516501

Software Mentioned

KETOCOMP
lme4
R

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