A ketogenic diet reduces metabolic syndrome-induced allodynia and promotes peripheral nerve growth in mice

Experimental Neurology
Michael A CooperDouglas E Wright

Abstract

Current experiments investigated whether a ketogenic diet impacts neuropathy associated with obesity and prediabetes. Mice challenged with a ketogenic diet were compared to mice fed a high-fat diet or a high-fat diet plus exercise. Additionally, an intervention switching to a ketogenic diet following 8 weeks of high-fat diet was performed to compare how a control diet, exercise, or a ketogenic diet affects metabolic syndrome-induced neural complications. When challenged with a ketogenic diet, mice had reduced bodyweight and fat mass compared to high-fat-fed mice, and were similar to exercised, high-fat-fed mice. High-fat-fed, exercised and ketogenic-fed mice had mildly elevated blood glucose; conversely, ketogenic diet-fed mice were unique in having reduced serum insulin levels. Ketogenic diet-fed mice never developed mechanical allodynia contrary to mice fed a high-fat diet. Ketogenic diet fed mice also had increased epidermal axon density compared all other groups. When a ketogenic diet was used as an intervention, a ketogenic diet was unable to reverse high-fat fed-induced metabolic changes but was able to significantly reverse a high-fat diet-induced mechanical allodynia. As an intervention, a ketogenic diet also increased ...Continue Reading

References

Aug 2, 2000·The American Journal of Clinical Nutrition·J F Horowitz, S Klein
Mar 15, 2005·Physiology & Behavior·Denize R ZieglerCarlos-Alberto Gonçalves
Dec 17, 2008·Epilepsia·James W Wheless
Dec 31, 2009·PloS One·David N RuskinSusan A Masino
Dec 7, 2011·Experimental Diabetes Research·B L GuilfordD E Wright
Mar 15, 2012·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Ahmet Höke
Mar 19, 2013·The Journal of Pain : Official Journal of the American Pain Society·David N RuskinSusan A Masino
May 18, 2013·Journal of Child Neurology·Susan A Masino, David N Ruskin
Jun 5, 2013·Journal of Diabetes and Its Complications·A Gordon Smith, J Robinson Singleton
Jun 27, 2013·European Journal of Clinical Nutrition·A PaoliK A Grimaldi
Jul 19, 2013·The International Journal of Neuroscience·Giovane S GaldinoAndrea C Perez
Aug 10, 2013·Annals of Neurology·Brian Callaghan, Eva Feldman
Nov 23, 2013·The Journal of Pharmacology and Experimental Therapeutics·Jiacheng MaRick T Dobrowsky
Feb 22, 2014·International Journal of Environmental Research and Public Health·Antonio Paoli
Oct 31, 2014·Neurology·Pavel KleinGregory C Mathews
Nov 13, 2014·Annals of Neurology·J Robinson SingletonA Gordon Smith
Dec 10, 2016·Journal of the Peripheral Nervous System : JPNS·Michael A CooperDouglas E Wright
Jan 18, 2017·The Journal of Clinical Investigation·Nigel A CalcuttPaul Fernyhough
May 10, 2017·Journal of the Peripheral Nervous System : JPNS·Elliot TurkiewAhmet Höke

❮ Previous
Next ❯

Citations

Jun 18, 2020·Frontiers in Cellular Neuroscience·Filipa Bouçanova, Roman Chrast
May 12, 2019·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Lindsay A Zilliox, James W Russell
Jan 14, 2021·Scientific Reports·David N RuskinSusan A Masino
Dec 12, 2020·Medical Hypotheses·L KeithM Carmody
Nov 12, 2021·Disease Models & Mechanisms·Stéphanie A Eid, Eva L Feldman
May 20, 2020·Diabetes Spectrum : a Publication of the American Diabetes Association·Jennifer D MerrillWilliam S Yancy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.