A key role for MAM in mediating mitochondrial dysfunction in Alzheimer disease

Cell Death & Disease
Estela Area-GomezEric A Schon

Abstract

In the last few years, increased emphasis has been devoted to understanding the contribution of mitochondria-associated endoplasmic reticulum (ER) membranes (MAM) to human pathology in general, and neurodegenerative diseases in particular. A major reason for this is the central role that this subdomain of the ER plays in metabolic regulation and in mitochondrial biology. As such, aberrant MAM function may help explain the seemingly unrelated metabolic abnormalities often seen in neurodegeneration. In the specific case of Alzheimer disease (AD), besides perturbations in calcium and lipid homeostasis, there are numerous documented alterations in mitochondrial behavior and function, including reduced respiratory chain activity and oxidative phosphorylation, increased free radical production, and altered organellar morphology, dynamics, and positioning (especially perinuclear mitochondria). However, whether these alterations are primary events causative of the disease, or are secondary downstream events that are the result of some other, more fundamental problem, is still unclear. In support of the former possibility, we recently reported that C99, the C-terminal processing product of the amyloid precursor protein (APP) derived fro...Continue Reading

References

Apr 10, 1992·Science·J A Hardy, G A Higgins
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·C Peterson, J E Goldman
Jul 18, 1995·Proceedings of the National Academy of Sciences of the United States of America·T Hutchin, G Cortopassi
Sep 15, 1994·Genomics·M Corral-DebrinskiD C Wallace
Jan 1, 1993·Genetic Epidemiology·H Payami, K Hoffbuhr
Jan 22, 1996·American Journal of Medical Genetics·M D BrownD C Wallace
Jan 1, 1997·British Medical Bulletin·A Haimovitz-FriedmanZ Fuks
Oct 2, 1998·Biological Psychiatry·G ZsurkaP Venetianer
Jul 14, 1999·American Journal of Medical Genetics·D EhrenkrantzK L Davis
Aug 7, 2001·Journal of Neuropathology and Experimental Neurology·A NunomuraM A Smith
Sep 22, 2001·Neurochemical Research·J W PettegrewR J McClure
Jan 18, 2002·Journal of Neurochemistry·C S CasleyM A Sharpe
Jul 9, 2002·Biochemical and Biophysical Research Communications·Maria Ankarcrona, Kjell Hultenby
Sep 12, 2002·Archives of Neurology·Hiroaki FukumotoMichael C Irizarry
Feb 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Rena LiYong Shen
Mar 17, 2004·The Journal of Biological Chemistry·Maud FriedenNicolas Demaurex
Jul 13, 2004·Proceedings of the National Academy of Sciences of the United States of America·Pinar E CoskunDouglas C Wallace
Aug 18, 2004·Journal of Molecular Neuroscience : MN·Luigi PuglielliDora M Kovacs
Aug 24, 2004·The Journal of Biological Chemistry·Kulandaivelu S VetrivelGopal Thinakaran
Sep 21, 2004·Journal of Bioenergetics and Biomembranes·Gary E Gibson, Hsueh-Meei Huang
Oct 1, 2004·The Journal of Biological Chemistry·Camilla A HanssonMaria Ankarcrona
Feb 18, 2005·Journal of Lipid Research·Yasuomi UranoTatsuhiko Kodama
Feb 26, 2005·Science·Gorazd B StokinLawrence S B Goldstein
Mar 5, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Lisa Mosconi
Apr 27, 2005·Annals of Neurology·Parvesh BubberGary E Gibson
Jan 7, 2006·Cell Death and Differentiation·D LindholmL Korhonen
Apr 14, 2006·Molecular Membrane Biology·Joanna M CordyAnthony J Turner
Jul 11, 2006·Journal of Neuropathology and Experimental Neurology·Akihiko NunomuraMark A Smith
Jul 29, 2006·Journal of Alzheimer's Disease : JAD·Michelangelo MancusoLuigi Murri
Jul 29, 2006·Journal of Alzheimer's Disease : JAD·Uta KeilWalter E Müller
Sep 1, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Latha DeviHindupur K Anandatheerthavarada
Sep 20, 2006·The Journal of Cell Biology·György CsordásGyörgy Hajnóczky
Nov 4, 2006·Science·Michel Goedert, Maria Grazia Spillantini
Dec 16, 2006·Current Alzheimer Research·Xi ChenShi Du Yan
Mar 16, 2007·Journal of Alzheimer's Disease : JAD·Pilar Gómez-Ramos, M Asunción Morán
Apr 27, 2007·The New England Journal of Medicine·Hans R WaterhamJames V Leonard

❮ Previous
Next ❯

Citations

Mar 20, 2018·Cell Death & Disease·Paolo Pinton
Apr 6, 2018·Molecular Neurobiology·Juan A GodoyNibaldo C Inestrosa
Nov 10, 2018·Journal of Alzheimer's Disease : JAD·Haowei JiangMorgan Newman
Mar 1, 2019·British Journal of Pharmacology·Lars M IttnerYazi D Ke
Jun 5, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Zhenbo ChenQinghe Yao
May 12, 2019·British Journal of Pharmacology·Radha Desai, Michelangelo Campanella
Sep 12, 2019·Frontiers in Pharmacology·Giovanna Cenini, Wolfgang Voos
Oct 6, 2019·Annual Review of Pathology·David C Chan
Mar 9, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xingjian Wang, Wei Zheng
May 31, 2020·Molecular Neurodegeneration·Wenzhang WangXiongwei Zhu
Sep 29, 2019·The Journal of Nutrition, Health & Aging·E E Martínez Leo, M R Segura Campos
Jul 31, 2018·Frontiers in Neuroscience·Marioly MüllerCésar Cárdenas
Dec 11, 2019·Current Alzheimer Research·Aston J WuKing-Ho Cheung
Aug 31, 2019·Oxidative Medicine and Cellular Longevity·Eduard KorkotianMenahem Segal
Aug 29, 2020·International Journal of Molecular Sciences·Rose Ghemrawi, Mostafa Khair
Jan 30, 2019·Oxidative Medicine and Cellular Longevity·Alex France M MonteiroLuciana Scotti
Nov 13, 2019·American Journal of Physiology. Endocrinology and Metabolism·Han ChengGuixia Wang
Dec 12, 2019·Frontiers in Aging Neuroscience·Anushka ChakravortyRavi Manjithaya
Jul 8, 2020·Proceedings of the National Academy of Sciences of the United States of America·Lien D NguyenBarbara E Ehrlich
Jun 6, 2018·Journal of Alzheimer's Disease : JAD·Yehong DuZhifang Dong
Jun 19, 2019·Biomolecules·Yoshimitsu Kiriyama, Hiromi Nochi
Apr 17, 2020·Frontiers in Molecular Neuroscience·Panpan WangWeidong Le
Oct 13, 2020·Journal of Alzheimer's Disease : JAD·Zhenting HuangZhiyou Cai
Oct 20, 2020·Frontiers in Cell and Developmental Biology·Alessandra Stacchiotti, Giovanni Corsetti
Nov 26, 2020·Cells·Maria Calvo-RodriguezBrian J Bacskai
Dec 15, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Fujie JiaFeng Li
Jan 5, 2021·Frontiers in Cell and Developmental Biology·Hyunsu JungSeok-Kyu Kwon
Jul 20, 2020·Neurobiology of Disease·Dawn H W LauChristopher C J Miller
Nov 9, 2020·Trends in Neurosciences·Maria Calvo-Rodriguez, Brian J Bacskai
Nov 2, 2020·Mechanisms of Ageing and Development·G AbateD Uberti

❮ Previous
Next ❯

Methods Mentioned

BETA
SMase

Related Concepts

Related Feeds

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Related Papers

Current Opinion in Genetics & Development
Estela Area-Gomez, Eric A Schon
Advances in Experimental Medicine and Biology
Estela Area-Gomez, Eric A Schon
Molecular and Cellular Neurosciences
Eric A Schon, Estela Area-Gomez
© 2022 Meta ULC. All rights reserved