A key role of the subdiaphragmatic vagus nerve in the depression-like phenotype and abnormal composition of gut microbiota in mice after lipopolysaccharide administration.

Translational Psychiatry
Jiancheng ZhangKenji Hashimoto

Abstract

The vagus nerve plays a role in the cross talk between the brain and gut microbiota, which could be involved in depression. The subdiaphragmatic vagus nerve serves as a major modulatory pathway between the brain and gut microbiota. Here, we investigated the effects of subdiaphragmatic vagotomy (SDV) on the depression-like phenotype and the abnormal composition of gut microbiota in mice after lipopolysaccharide (LPS) administration. LPS caused a depression-like phenotype, inflammation, increase in spleen weight, and downregulation of synaptic proteins in the medial prefrontal cortex (mPFC) in the sham-operated mice. In contrast, LPS did not produce a depression-like phenotype and downregulated synaptic proteins in the mPFC after SDV. The spleen weight and plasma levels of pro-inflammatory cytokines in the SDV + LPS group were lower than those of the sham + LPS group. Interestingly, there were positive correlations between the plasma levels of pro-inflammatory cytokines and spleen weight, suggesting a relationship between inflammatory events and spleen weight. Furthermore, LPS led to significant alterations in gut microbiota diversity in sham-operated mice, but not SDV-operated mice. In an unweighted UniFrac PCoA, the dots repres...Continue Reading

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Citations

Mar 4, 2021·International Journal of Molecular Sciences·Elisabet Navarro-TapiaVicente Andreu-Fernández
Apr 2, 2021·Neuropsychiatric Disease and Treatment·Jin ChenHe-Qing Zheng
Apr 25, 2021·Neuroscience and Biobehavioral Reviews·Yue WangAilin Luo
May 11, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Yan WeiKenji Hashimoto
May 30, 2021·Scientific Reports·Hiroyo Shinno-HashimotoKenji Hashimoto

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Methods Mentioned

BETA
protein assay
electrophoresis

Software Mentioned

Image Lab TM
SPSS
SCANET

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