A-kinase interacting protein 1 (AKIP1) associates with advanced overall disease condition, tumor properties, and unfavorable prognosis in hepatocellular carcinoma patients.

Journal of Clinical Laboratory Analysis
Tao Fang, Qi Lu

Abstract

The presented study aimed to investigate the association of A-kinase interacting protein 1 (AKIP1) expression with tumor properties, liver functions, cancer markers, and overall survival (OS) of hepatocellular carcinoma (HCC) patients. A total of 432 HCC patients receiving surgery were retrospectively reviewed in our study. Clinical characteristics of patients were obtained. Tumor tissue specimens of all patients were collected, and AKIP1 expression was evaluated by immunohistochemistry (IHC) assay. OS was assessed, and the median follow-up duration was 35.0 months. AKIP1 high expression was defined as total IHC score more than 3 and was further graded as AKIP1 high+ (IHC 4-6), AKIP1 high++ (IHC 7-9), and AKIP1 high+++ (IHC 10-12). About 265 (61.3%) patients presented with AKIP1 low expression and 167 (38.7%) patients had AKIP1 high expression. AKIP1 high expression correlated with higher performance status score (P = .006), largest tumor size ≥5.0 cm (P < .001), Barcelona clinic liver cancer (BCLC) stage B (vs stage A; P = .024), increased alpha-fetoprotein level (P = .036), and higher carbohydrate antigen 199 level (P < .001). AKIP1 high expression (P < .001) and increased AKIP1 expression grade (P < .001) both correlated wit...Continue Reading

References

Jan 24, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Josep M Llovet, Jordi Bruix
Oct 28, 2004·Gastroenterology·Jorge A Marrero, Anna S F Lok
May 2, 2009·Journal of the National Comprehensive Cancer Network : JNCCN·Al B BensonAndrew X Zhu
Jun 22, 2010·The Journal of Biological Chemistry·Nan GaoTakashi Okamoto
Oct 24, 2015·Nature Reviews. Cancer·Jens U MarquardtSnorri S Thorgeirsson
Jan 9, 2018·Lancet·Alejandro FornerJordi Bruix
Mar 10, 2018·Molecular and Cellular Biochemistry·Wenying ZhangChengbin Ma
Apr 16, 2019·Gastroenterology·Fasiha Kanwal, Amit G Singal
Apr 28, 2019·Nature Reviews. Gastroenterology & Hepatology·Quentin M AnsteeMathias Heikenwalder
Aug 3, 2019·Nature Reviews. Gastroenterology & Hepatology·Jordi BruixMaría Reig
Aug 24, 2019·Nature Reviews. Gastroenterology & Hepatology·Ju Dong YangLewis R Roberts

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Citations

Sep 11, 2021·Frontiers in Pharmacology·Ly PoroskÜlo Langel

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Methods Mentioned

BETA
xenograft

Software Mentioned

GraphPad
GraphPad Prism
SPSS

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