A kinetic analysis of the effects of beta-phenylethylamine on the concentrations of dopamine and its metabolites in the rat striatum

Journal of Pharmaceutical Sciences
S SatoA Koshiro

Abstract

The purpose of this investigation was to determine whether the increase in the dopamine (DA) concentration in the rat striatum after a rapid iv injection of beta-phenylethylamine (PEA) can be quantitatively explained by the alteration of the striatum PEA concentration using a constructed DA metabolism model and to examine whether the time courses of the striatum DA metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) concentration can be described by this DA metabolism model. The time courses of PEA concentration in plasma and the striatum were determined by gas chromatography-mass spectrometry. The plasma PEA concentration was described by a two-compartment model with nonlinear elimination kinetics. The striatum PEA concentration was about 10 times higher than the plasma PEA concentration. The time course of the striatum PEA concentration was described by a diffusion-limited model including a Michaelis-Menten type transport system from plasma to the striatum and nonlinear elimination from the striatum. The DA concentration in the striatum increased immediately after PEA injection. In contrast, the DOPAC concentration in the striatum decreased immediately. HVA concentration in the striatum increased gr...Continue Reading

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Citations

Dec 14, 2001·Journal of Neuroscience Methods·Jonas BergquistJerzy Silberring
Oct 30, 2016·Journal of Pharmacological and Toxicological Methods·Cinzia NasutiRosita Gabbianelli
Jan 30, 2018·Frontiers in Pharmacology·Grazia RutiglianoRiccardo Zucchi
Oct 1, 2020·Organic & Biomolecular Chemistry·Sumin LeeYoungmin You
Mar 28, 2019·Oxidative Medicine and Cellular Longevity·Laura BordoniRosita Gabbianelli
Sep 12, 2006·Progress in Neurobiology·Scott A Burchett, T Philip Hicks

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