A kinetic analysis of the effects of beta-phenylethylamine on the concentrations of dopamine and its metabolites in the rat striatum

Journal of Pharmaceutical Sciences
S SatoA Koshiro


The purpose of this investigation was to determine whether the increase in the dopamine (DA) concentration in the rat striatum after a rapid iv injection of beta-phenylethylamine (PEA) can be quantitatively explained by the alteration of the striatum PEA concentration using a constructed DA metabolism model and to examine whether the time courses of the striatum DA metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) concentration can be described by this DA metabolism model. The time courses of PEA concentration in plasma and the striatum were determined by gas chromatography-mass spectrometry. The plasma PEA concentration was described by a two-compartment model with nonlinear elimination kinetics. The striatum PEA concentration was about 10 times higher than the plasma PEA concentration. The time course of the striatum PEA concentration was described by a diffusion-limited model including a Michaelis-Menten type transport system from plasma to the striatum and nonlinear elimination from the striatum. The DA concentration in the striatum increased immediately after PEA injection. In contrast, the DOPAC concentration in the striatum decreased immediately. HVA concentration in the striatum increased gr...Continue Reading


Apr 1, 1978·Journal of Pharmacokinetics and Biopharmaceutics·K YamaokaT Uno
Mar 1, 1979·Clinical Pharmacology and Therapeutics·L B SheinerJ Ham
Jun 1, 1976·European Journal of Pharmacology·B H Westerink, J Korf
Dec 1, 1971·The American Journal of Physiology·W H Oldendorf
Jul 15, 1983·Archives of Biochemistry and Biophysics·L B Pearce, J A Roth
Sep 10, 1982·European Journal of Pharmacology·R L HaugerS M Paul
Mar 1, 1981·Journal of Neurochemistry·E M DeMetA E Halaris
Apr 1, 1995·Biological & Pharmaceutical Bulletin·S Sato, A Koshiro
Jan 1, 1995·The Journal of Neuropsychiatry and Clinical Neurosciences·H C Sabelli, J I Javaid
Dec 1, 1994·General Pharmacology·P H Yu
Jan 1, 1994·Progress in Neuro-psychopharmacology & Biological Psychiatry·R L O'Reilly, B A Davis
Aug 15, 1994·Analytical Biochemistry·N D HuebertK D Haegele
Mar 21, 1994·European Journal of Pharmacology·A V JuorioM Y Zhu
Jan 1, 1994·Progress in Neuro-psychopharmacology & Biological Psychiatry·B A Davis, A A Boulton
Jun 1, 1993·Cellular and Molecular Neurobiology·P R Paetsch, A J Greenshaw

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