A kinetic study on the reactivity of azanone (HNO) toward its selected scavengers: Insight into its chemistry and detection

Nitric Oxide : Biology and Chemistry
Renata Smulik-IzydorczykAdam Sikora

Abstract

Recently, azanone (HNO), which is the protonated one-electron reduction product of ·NO, has gained considerable attention due to its unique pharmacological effects. Although there has been much progress in understanding HNO biology and chemistry, it remains the most elusive reactive nitrogen species. Herein, we applied the competition kinetics method, based on two parallel HNO reactions with the different scavengers and molecular oxygen (kO2 = (1.8 ± 0.3) × 104 M-1 s-1), to determine the rate constants for the reactions of HNO with its selected co-reactants. The rate constants for the reactions of HNO with nitrite (k = (5.0 ± 0.9) × 103 M-1s-1), hydroxylamine (k = (2.1 ± 0.4) × 104 M-1s-1), sulfite (k = (1.2 ± 0.2) × 106 M-1 s-1), thiosulfate (k = (2.2 ± 0.7) × 104 M-1 s-1), benzenesulfinate (k = (4.4 ± 0.9) × 104 M-1 s-1), 2-bromobenzenesulfinate (k = (5.0 ± 1.2) × 104 M-1 s-1), nitrosoglutathione (k = (2.4 ± 0.7) × 104 M-1s-1), nitrosobenzene (k > 1.5 × 105 M-1 s-1), 2-nitroso-1-naphthol (k = (1.0 ± 0.2) × 106 M-1 s-1), triphenylphosphine (k > 7.3 × 106 M-1 s-1), triphenylphosphine-3,3',3″-trisulfonate (k = (3.0 ± 0.5) × 106 M-1 s-1), tris-carboxyethylphosphine (k = (1.2 ± 0.3) × 107 M-1 s-1), a triphenylphosphine-based P-CM ...Continue Reading

Citations

Nov 27, 2018·Angewandte Chemie·Weiwei AnAlexander R Lippert
Jan 16, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Julián PerdoménicoLeonardo D Slep
Jan 2, 2021·Journal of Inorganic Biochemistry·Sebastián A SuarezFabio A Doctorovich
Oct 27, 2020·Frontiers in Chemistry·Adam SikoraBalaraman Kalyanaraman
May 6, 2021·Cell Biochemistry and Biophysics·Renata Smulik-IzydorczykAdam Sikora
Aug 28, 2021·Chemical Science·Cecilia Mariel GallegoFabio Doctorovich

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