A knowledge-anchored integrative image search and retrieval system

Journal of Digital Imaging
Selnur ErdalMetin N Gurcan


Clinical data that may be used in a secondary capacity to support research activities are regularly stored in three significantly different formats: (1) structured, codified data elements; (2) semi-structured or unstructured narrative text; and (3) multi-modal images. In this manuscript, we will describe the design of a computational system that is intended to support the ontology-anchored query and integration of such data types from multiple source systems. Additional features of the described system include (1) the use of Grid services-based electronic data interchange models to enable the use of our system in multi-site settings and (2) the use of a software framework intended to address both potential security and patient confidentiality concerns that arise when transmitting or otherwise manipulating potentially privileged personal health information. We will frame our discussion within the specific experimental context of the concept-oriented query and integration of correlated structured data, narrative text, and images for cancer research.


Oct 7, 1998·Journal of the American Medical Informatics Association : JAMIA·K E CampbellE H Shortliffe
Oct 30, 1998·JAMA : the Journal of the American Medical Association·David W BatesD L Seger
Jun 1, 2000·Journal of the American Medical Informatics Association : JAMIA·James J Cimino
Jun 8, 2000·Journal of Digital Imaging·E A El-KwaeM R Kabuka
Jun 10, 2000·Journal of Digital Imaging·C P Langlotz
Feb 7, 2001·Radiographics : a Review Publication of the Radiological Society of North America, Inc·R K TairaR M Jakobovits
Apr 27, 2001·Telemedicine Journal and E-health : the Official Journal of the American Telemedicine Association·J KuchenbeckerW Behrens-Baumann
Aug 28, 2001·Statistics in Medicine·R G MarksS J Ruberg
Jan 10, 2002·Nature·D Butler
Feb 5, 2002·Proceedings·F C TsuiC C Chang
Feb 14, 2002·Trends in Biotechnology·Lara Marks, Emmett Power
Apr 30, 2002·Journal of Biomedical Informatics·W Sujansky
Sep 28, 2002·American Journal of Preventive Medicine·Michael D LewisPatrick W Kelley
Nov 20, 2002·American Journal of Health Behavior·James M Craver, Robert S Gold
Jan 2, 2003·Journal of the American Medical Informatics Association : JAMIA·David W BatesH C Mullins
Jan 17, 2003·Mayo Clinic Proceedings·Jon O EbbertPatricia J Erwin
Mar 14, 2003·JAMA : the Journal of the American Medical Association·Nancy S SungDavid Rimoin
Jun 10, 2004·Journal of the American Medical Informatics Association : JAMIA·Carol FriedmanGeorge Hripcsak
Aug 31, 2004·Radiology·Samuel G ArmatoLung Image Database Consortium Research Group
Sep 8, 2004·Artificial Intelligence in Medicine·Xuezhong ZhouRuen Zhang
Jan 27, 2005·AJR. American Journal of Roentgenology·Bijoy J ThomasDaniel I Rosenthal
Apr 2, 2005·Journal of the American Medical Informatics Association : JAMIA·Kin Wah FungLaura Roth
Jun 25, 2005·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Philip R O PayneDavid Dowdy
Dec 6, 2005·Journal of Clinical Monitoring and Computing·Ignacio Blanquer EspertJ Damià Segrelles Quilis
Dec 13, 2005·Journal of Digital Imaging·Brent J LiuH K Huang
May 27, 2006·The British Journal of Radiology·A P TomsP Wilson
Nov 15, 2006·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Aaron W C KamauuDavid E Avrin
Apr 10, 2007·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Matthew S BrownJonathan G Goldin
May 8, 2007·Journal of Biomedical Informatics·Philip R O PayneJustin B Starren


Jun 10, 2010·Medical Physics·T WoloszynskiM Kurzynski
Jan 5, 2017·Journal of Digital Imaging·Chris MeenanSteve G Langer
Aug 28, 2020·Nature Reviews. Nephrology·Laura BarisoniUlysses G J Balis

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