A label-free and portable multichannel surface plasmon resonance immunosensor for on site analysis of antibiotics in milk samples

Biosensors & Bioelectronics
Fátima FernándezM Pilar Marco

Abstract

Techniques for immunosensing like surface plasmon resonance (SPR) may respond to the need for rapid screening methods to improve food safety. This paper describes the development of a novel portable six channel SPR biosensor based on the plasmon of gold diffraction grating surface for simultaneous multianalyte antibiotic detection in milk samples. Representative congeners from three important antibiotic families (FQs: fluoroquinolones, SAs: sulfonamides and CAP: phenicols) were chosen for this study. The chips are covalently biofunctionalized with haptenized proteins by means of a previously formed mixed self assembled monolayer (m-SAM) prepared using two types of mercapto alkyl reagents containing polyethyleneglycol (PEG) units. The samples or standards are mixed with specific polyclonal antibodies and injected into the sensor device. The detectability accomplished is very good (i.e. in buffer, enrofloxacin, 0.30 μg L(-1); sulfapyridine, 0.29 μg L(-1); and chloramphenicol, 0.26 μg L(-1)) and whole milk samples can be analyzed directly without clean-up steps, by just diluting the sample five times with water to remove non-specific interferences caused by the matrix. Although the detectability of CAP regarding the MRPL (minimum ...Continue Reading

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Citations

Apr 25, 2012·Analytical and Bioanalytical Chemistry·Julien Breault-Turcot, Jean-Francois Masson
Aug 3, 2013·Analytical and Bioanalytical Chemistry·A MurianoM-P Marco
Jan 7, 2014·Biosensors & Bioelectronics·Tomáš RiedelEduard Brynda
Apr 12, 2011·Journal of Agricultural and Food Chemistry·Fátima FernándezM Pilar Marco
Jun 9, 2012·International Journal of Nanomedicine·ShuQi WangUtkan Demirci
Nov 1, 2012·Sensors·Jeong-Yeol Yoon, Bumsang Kim
Apr 28, 2012·Biosensors & Bioelectronics·Felipe ConzueloJosé M Pingarrón
Mar 6, 2012·Biosensors & Bioelectronics·Fátima FernándezM-Pilar Marco
Jan 13, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Mona AlibolandiMohammad Ramezani
Sep 24, 2016·Biosensors & Bioelectronics·Zhoumin LiDanke Xu
Apr 11, 2017·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Rajesh SeenivasanClemens Burda
Dec 4, 2015·The Analyst·Kristy S McKeatingJean-Francois Masson
Jan 15, 2015·Biosensors·Nawfal Adam Mungroo, Suresh Neethirajan
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Jul 6, 2012·Nanoscale·Yih-Fan ChenDavid Erickson
Sep 24, 2013·Lab on a Chip·Sixing LiTony Jun Huang
Sep 20, 2011·Journal of Separation Science·Akihide HemmiHizuru Nakajima
Jan 12, 2013·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Yan Z LiuJian P Wang
Dec 14, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Noemi BellassaiJurriaan Huskens
Jul 2, 2016·Essays in Biochemistry·Pavel DamborskýJaroslav Katrlík
Jul 10, 2018·Analytical and Bioanalytical Chemistry·Philipp FruhmannM-Pilar Marco
Nov 28, 2018·Sensors·Riikka PeltomaaMaría C Moreno-Bondi
Dec 11, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xing ShenHongtao Lei
Jan 27, 2012·Analytical and Bioanalytical Chemistry·T F McGrathT L Fodey
Apr 13, 2019·Sensors·Abdul ShakoorDavid R S Cumming
Nov 21, 2014·Biosensors·Nawfal Adam Mungroo, Suresh Neethirajan
May 27, 2021·Biosensors & Bioelectronics·Jun Jie OngAbdul W Basit
Apr 22, 2014·Chemical Reviews·Onur TokelUtkan Demirci
Oct 31, 2012·Bioconjugate Chemistry·Nuria TortM-Pilar Marco
Aug 1, 2019·ACS Sensors·Daria KotlarekJakub Dostálek

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