A label-free electrochemical sensor for detection of mercury(II) ions based on the direct growth of guanine nanowire

Journal of Hazardous Materials
Yan Li HuangNian Bing Li

Abstract

A simple, sensitive and label-free electrochemical sensor is developed for detection of Hg(2+) based on the strong and stable T-Hg(2+)-T mismatches. In the presence of Mg(2+), the parallel G-quadruplex structures could be specifically recognized and precipitated in parallel conformation. Therefore, the guanine nanowire was generated on the electrode surface, triggering the electrochemical H2O2-mediated oxidation of 3,3',5,5'-tetramethylbenzidine (TMB). In this research, a new method of signal amplification for the quantitative detection of Hg(2+) was described based on the direct growth of guanine nanowire via guanine nanowire. Under optimum conditions, Hg(2+) was detected in the range of 100 pM-100 nM, and the detection limit is 33 pM. Compared to the traditional single G-quadruplex label unit, this electrochemical sensor showed high sensitivity and selectivity for detecting Hg(2+).

References

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Dec 10, 2015·Biosensors & Bioelectronics·Zhong Feng GaoNian Bing Li

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Citations

Sep 21, 2016·Journal of Fluorescence·Muhammad SaleemMuhammad Hanif
Sep 29, 2021·ACS Applied Materials & Interfaces·Xuliang PangWeidong Shi

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