A label-free nanostructured plasmonic biosensor based on Blu-ray discs with integrated microfluidics for sensitive biodetection

Biosensors & Bioelectronics
Gerardo A López-MuñozLaura M Lechuga

Abstract

Nanostructure-based plasmonic biosensors have quickly positioned themselves as interesting candidates for the design of portable optical biosensor platforms considering the potential benefits they can offer in integration, miniaturization, multiplexing, and real-time label-free detection. We have developed a simple integrated nanoplasmonic sensor taking advantage of the periodic nanostructured array of commercial Blu-ray discs. Sensors with two gold film thicknesses (50 and 100nm) were fabricated and optically characterized by varying the oblique-angle of the incident light in optical reflectance measurements. Contrary to the use normal light incidence previously reported with other optical discs, we observed an enhancement in sensitivity and a narrowing of the resonant linewidths as the light incidence angle was increased, which could be related to the generation of Fano resonant modes. The new sensors achieve a figure of merit (FOM) up to 35 RIU-1and a competitive bulk limit of detection (LOD) of 6.3×10-6RIU. These values significantly improve previously reported results obtained with normal light incidence reflectance measurements using similar structures. The sensor has been combined with versatile, simple, ease to-fabricat...Continue Reading

Citations

Jan 25, 2019·Scientific Reports·Salman Daniel, Prince Bawuah
Feb 13, 2018·Expert Review of Molecular Diagnostics·Andrea CsákiWolfgang Fritzsche
Nov 19, 2018·Biosensors & Bioelectronics·Gabriel Sancho-FornesÁngel Maquieira
Dec 19, 2020·Nanomaterials·Gerardo A Lopez-MuñozJavier Ramón-Azcón
May 6, 2021·Nanomaterials·Petra UrbancovaJaroslav Kovac
Sep 13, 2018·ACS Applied Materials & Interfaces·Justin R SperlingAlasdair W Clark
Aug 5, 2017·Analytical Chemistry·Miquel Avella-OliverÁngel Maquieira
Dec 24, 2021·Nanoscale·Qi WangKe-Ke Zhang
Dec 24, 2021·Frontiers in Bioengineering and Biotechnology·Judith Camaló VilaJavier Ramón-Azcón

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