A labeling study on the formation of perillene by submerged cultured oyster mushroom, Pleurotus ostreatus

Applied Microbiology and Biotechnology
Ulrich KringsRalf G Berger

Abstract

The conversion of beta-myrcene to the furanoid flavour compound perillene by Pleurotus ostreatus was investigated using trideutero beta-myrcene, trideutero alpha-(Z)-acaridiol and non-labeled 1,2- and 3,10-epoxy-beta-myrcene, alpha,alpha-acarilactol, and perillene as substrates. Myrcene diols were formed from the cleavage of myrcene epoxides, but only alpha-(Z)-acaridiol, a 1,4-butanediol derivative most likely generated through a base-catalysed epoxide opening, was a suitable precursor of perillene. Once formed, this key intermediate was rapidly oxidised and the resulting cyclic lactol was dehydrated to yield perillene. Bioconversion of the supplemented perillene to alpha,alpha-acariolide indicated that perillene was another intermediate of the pathway and prone to further oxidative degradation. The data suggest that the fungus converted the cytotoxic beta-myrcene in its environment into a metabolically useable carbon source along this route.

References

Mar 6, 1998·Applied Microbiology and Biotechnology·U Krings, R G Berger
Feb 19, 2002·Current Opinion in Biotechnology·A Steinreiber, K Faber
Aug 9, 2002·Journal of Agricultural and Food Chemistry·Mitsuo Miyazawa, Masashi Ohsawa
Aug 19, 2003·Journal of Chemical Ecology·Atsuko MizoguchiYasumasa Kuwahara
Aug 29, 2003·Current Opinion in Biotechnology·Erik J de Vries, Dick B Janssen
Mar 24, 2004·Trends in Biotechnology·Martha S Smit
Jul 28, 2006·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Rilka M TaskovaRalf G Berger
Nov 25, 2006·Applied Microbiology and Biotechnology·Dongliang HuaPing Xu

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