PMID: 36478Jul 1, 1979

A laboratory animal model for malignant hyperpyrexia

The Journal of Pharmacology and Experimental Therapeutics
C G Durbin, H Rosenberg

Abstract

Strandard laboratory rabbits which are not genetically susceptible to malignant hyperpyrexia were anesthetized with either halothane or pentobarbital. Administration of caffeine in 125 mg increments produced a syndrome strongly resembling malignant hyperpyrexia in rabbits anesthetized with halothane. All these animals became rigid, hyperpyrexic, acidotic and hyperkalemic, whereas caffeine-treated, pentobarbital-anesthetized animals developed only mild acidosis. Pentobarbital alone and halothane alone caused no changes in measured variables. This model for malignant hyperpyrexia resembles the naturally occurring disease more closely than several preceding pharmacologic models.

Related Concepts

DRUG Screen Quant Caffeine
Muscle Rigidity
Halothane
Diabutal
Quick-Pep
Anesthesia Procedures
Drug Interactions
Caffeine Measurement
Caffeine
Narcotan

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Related Papers

Clinical and Experimental Pharmacology & Physiology
P S FosterM A Denborough
Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
B W JafekT F Gumprecht
© 2020 Meta ULC. All rights reserved