A lack of commitment for over 500 million years: conserved animal stem cell pluripotency.

The EMBO Journal
A Aziz Aboobaker, Damian Kao

Abstract

Stem cells, both adult and germline, are the key cells underpinning animal evolution. Yet, surprisingly little is known about the evolution of their shared key feature: pluripotency. Now using genome-wide expression profiling of pluripotent planarian adult stem cells (pASCs), Önal et al (2012) present evidence for deep molecular conservation of pluripotency. They characterise the expression profile of pASCs and identify conserved expression profiles and functions for genes required for mammalian pluripotency. Their analyses suggest that molecular pluripotency mechanisms may be conserved, and tantalisingly that pluripotency in germ stem cells (GSCs) and somatic stem cells (SSCs) may have had shared common evolutionary origins.

References

Jul 29, 2006·Development, Growth & Differentiation·Tetsutaro HayashiKiyokazu Agata
Oct 1, 2009·Molecular Reproduction and Development·Ben Ewen-CampenCassandra G M Extavour
Nov 26, 2010·Development·Celina E JulianoGary M Wessel
Mar 1, 2011·Trends in Cell Biology·A Aziz Aboobaker

❮ Previous
Next ❯

Citations

Sep 26, 2013·Developmental Biology·Farah Jaber-HijaziA Aziz Aboobaker

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.