A lack of experience-dependent plasticity after more than a decade of recovered sight

Psychological Science
Elizabeth HuberIone Fine

Abstract

In 2000, monocular vision was restored to M. M., who had been blind between the ages of 3 and 46 years. Tests carried out over 2 years following the surgery revealed impairments of 3-D form, object, and face processing and an absence of object- and face-selective blood-oxygen-level-dependent responses in ventral visual cortex. In the present research, we reexamined M. M. to test for experience-dependent recovery of visual function. Behaviorally, M. M. remains impaired in 3-D form, object, and face processing. Accordingly, we found little to no evidence of the category-selective organization within ventral visual cortex typically associated with face, body, scene, or object processing. We did observe remarkably normal object selectivity within lateral occipital cortex, consistent with M. M.'s previously reported shape-discrimination performance. Together, these findings provide little evidence for recovery of high-level visual function after more than a decade of visual experience in adulthood.

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Citations

Aug 25, 2015·Current Biology : CB·Ayelet McKytonEhud Zohary
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May 1, 2019·Proceedings of the National Academy of Sciences of the United States of America·Elizabeth HuberIone Fine
Jul 21, 2017·Annual Review of Vision Science·Barbara Dosher, Zhong-Lin Lu
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Jan 24, 2018·Vision Research·Ipek OrucThais Ton

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Software Mentioned

FsFast
FMRIB Software Library Brain Extraction Tool
Analysis of Functional and Neural Images ( AFNI )
FreeSurfer

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