A lamin in lower eukaryotes?

Nucleus
Petros BatsiosRalph Gräf

Abstract

Lamins are the major components of the nuclear lamina and serve not only as a mechanical support, but are also involved in chromatin organization, epigenetic regulation, transcription and mitotic events. Despite these universal tasks, lamins have so far been found only in metazoans. Yet, recently we have identified Dictyostelium NE81 as the first lamin-like protein in a lower eukaryote. Based on the current knowledge, we draw a model for nuclear envelope organization in Dictyostelium in this Extra View and we review the experimental data that justified this classification. Furthermore we provide unpublished data underscoring the requirement of posttranslational CaaX-box processing for proper protein localization at the nuclear envelope. Sequence comparison of NE81 sequences from four Dictyostelia with bona fide lamins illustrates the evolutional relationship between these proteins. Under certain conditions these usually unicellular social amoebae congregate to form a multicellular body. We propose that the evolution of the lamin-like NE81 went along with the invention of multicellularity.

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Citations

Jan 16, 2013·Journal of Clinical Bioinformatics·Walter ArancioGiuseppe Pizzolanti
Jul 26, 2014·European Journal of Cell Biology·Paul SchilfReimer Stick
Mar 11, 2016·Current Opinion in Cell Biology·Masaaki IwamotoTokuko Haraguchi
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May 9, 2015·European Journal of Cell Biology·Ralph GräfIrene Meyer
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May 9, 2014·Frontiers in Plant Science·Malgorzata Ciska, Susana Moreno Díaz de la Espina
May 18, 2016·Molecular and Biochemical Parasitology·Richard McCulloch, Miguel Navarro
Sep 30, 2016·European Journal of Protistology·Mariia BerdievaAndrew Goodkov
Mar 5, 2019·Journal of Experimental Botany·Malgorzata CiskaSusana Moreno Díaz de la Espina
Jun 5, 2020·The Journal of Eukaryotic Microbiology·Earl WeidnerRobin M Overstreet
Aug 21, 2020·Molecular Systems Biology·Jessica M BryantArtur Scherf
Feb 20, 2019·Cells·Marianne GrafeRalph Gräf

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Methods Mentioned

BETA
lipidation
geranylgeranylation

Software Mentioned

BLAST

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