A Langevin model of physical forces in cell volume fluctuations

Journal of Biomechanics
Steven M ZehnderThomas E Angelini

Abstract

Cells interact mechanically with their physical surroundings by attaching to the extracellular matrix or other cells and contracting the cytoskeleton. Cells do so dynamically, exhibiting fluctuating contractile motion in time. In monolayers, these dynamic contractions manifest as volume fluctuations, which involve the transport of fluid in and out of the cell. An integrated understanding of cell elasticity, actively generated stresses, and fluid transport has not yet been developed. Here we apply a minimal model of these forces to cell volume fluctuation data, elucidating the dynamic behavior of cells within monolayers.

References

Feb 1, 1992·Seminars in Cell Biology·M V Bennett, V K Verselis
Aug 1, 1994·Biophysical Journal·D V ZhelevR M Hochmuth
Sep 1, 1996·The Journal of Membrane Biology·M M Timbs, K R Spring
Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·R J Pelham, Y l Wang
Mar 30, 1999·Biophysical Journal·M Dembo, Y L Wang
Feb 8, 2002·American Journal of Physiology. Cell Physiology·Ning WangDimitrije Stamenović
Nov 19, 2005·Science·Dennis E DischerYu-Li Wang
Jun 7, 2006·The Journal of Cell Biology·Clifford P BrangwynneDavid A Weitz
Aug 23, 2006·Cell·Adam J EnglerDennis E Discher
Jan 20, 2007·Science·Daisuke MizunoF C Mackintosh
Jan 8, 2009·Physiological Reviews·Else K HoffmannStine F Pedersen
May 24, 2011·Nature Materials·Dhananjay T TambeXavier Trepat
Jan 22, 2015·Biophysical Journal·Steven M ZehnderThomas E Angelini

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Citations

Nov 23, 2016·Journal of Biomechanics·Vi Q Ha, George Lykotrafitis
Nov 13, 2019·ACS Applied Materials & Interfaces·Luke G MajorYu Suk Choi

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