A large animal survival model (Sus scrofa) of extremity ischemia/reperfusion and neuromuscular outcomes assessment: a pilot study

The Journal of Trauma
Gabriel E BurkhardtTodd E Rasmussen

Abstract

Extremity ischemia/reperfusion has been studied mostly in small-animal models with limited characterization of neuromuscular or functional outcome. The objective of this experiment was to report a large-animal survival model of extremity ischemia/reperfusion using circulating, electromyographic (EMG), gate, and histologic measures of injury and limb recovery. Sus scrofa swine (n = 6; mean, 83 kg) were randomized to iliac artery occlusion for 0 (control), 1 (1 HR), 3 (3 HR), or 6 (6 HR) hours. Restoration of flow after a standard large-vessel reconstructive technique (thrombectomy, heparin irrigation, and patch angioplasty) was performed in each of the control, 1HR, 3HR, and 6HR animals, whereas one animal had iliac artery segment excision with no restoration (NR) of axial flow. One animal had operative exposure but no intervention on the iliac artery (sham). Animals were recovered and closely monitored for 2 weeks. Indicators of ischemia/reperfusion and functional recovery, including circulating markers, EMG measures (complex motor action potential), and Tarlov gate scoring (0-4; 0, insensate/paralyzed to 4, normal posture and no gait abnormality) were measured at 24 hours and 72 hours and 7 days and 14 days. Muscle (peroneus) ...Continue Reading

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Citations

Mar 28, 2012·The British Journal of Surgery·T J Percival, T E Rasmussen
Nov 28, 2012·Atherosclerosis·Shamim LotfiBijan Modarai
May 17, 2014·Prehospital Emergency Care : Official Journal of the National Association of EMS Physicians and the National Association of State EMS Directors·Vikhyat S BebartaSusan Boudreau
Aug 16, 2014·The Journal of Surgical Research·Thomas J PercivalTodd E Rasmussen
Aug 28, 2014·The Journal of Trauma and Acute Care Surgery·Bijan S KheirabadiMichael A Dubick
Oct 1, 2013·Plastic and Reconstructive Surgery·Srikanth VasudevanJonathan J Cheng
Apr 24, 2013·The Journal of Trauma and Acute Care Surgery·Bijan S KheirabadiLorne H Blackbourne
Apr 30, 2017·The Journal of Trauma and Acute Care Surgery·Norman M RichTodd E Rasmussen
Jul 9, 2016·Organogenesis·Zayd FarahJia-Qiang He

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