A large case-control study on vaccination as risk factor for multiple sclerosis

Neurology
Alexander HapfelmeierBernhard Hemmer

Abstract

To investigate the hypothesis that vaccination is a risk factor for multiple sclerosis (MS) by use of German ambulatory claims data in a case-control study. Using the ambulatory claims data of the Bavarian Association of Statutory Health Insurance Physicians covering 2005-2017, logistic regression models were used to assess the relation between MS (n = 12,262) and vaccinations in the 5 years before first diagnosis. Participants newly diagnosed with Crohn disease (n = 19,296) or psoriasis (n = 112,292) and participants with no history of these autoimmune diseases (n = 79,185) served as controls. The odds of MS were lower in participants with a recorded vaccination (odds ratio [OR] 0.870, p < 0.001 vs participants without autoimmune disease; OR 0.919, p < 0.001 vs participants with Crohn disease; OR 0.973, p = 0.177 vs participants with psoriasis). Lower odds were most pronounced for vaccinations against influenza and tick-borne encephalitis. These effects were consistently observed for different time frames, control cohorts, and definitions of the MS cohort. Effect sizes increased toward the time of first diagnosis. Results of the present study do not reveal vaccination to be a risk factor for MS. On the contrary, they consisten...Continue Reading

References

Aug 1, 1997·Multiple Sclerosis : Clinical and Laboratory Research·F MokhtarianE Lichstein
Oct 26, 1999·Neurology·G RistoriM Salvetti
Feb 15, 2001·The New England Journal of Medicine·A AscherioA M Walker
Apr 23, 2003·Archives of Neurology·Frank DeStefanoUNKNOWN Vaccine Safety Datalink Research Group, National Immunization Program, Centers for Disease Control and Prevention
Dec 6, 2003·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·M ZorzonG Cazzato
Nov 24, 2004·Lancet Neurology·Ruth Ann Marrie
Feb 12, 2009·Neuroepidemiology·Sreeram V RamagopalanUNKNOWN Canadian Collaborative Study Group
Dec 25, 2012·Multiple Sclerosis : Clinical and Laboratory Research·Ruth Ann MarrieJames Blanchard
Dec 7, 2013·Neurology·Giovanni RistoriMarco Salvetti
Jan 7, 2015·JAMA : the Journal of the American Medical Association·Nikolai Madrid SchellerAnders Hviid
Jan 1, 2014·Human Antibodies·Mohammad Mahdi EftekharianMehrdokht Mazdeh
Sep 9, 2016·Journal of Neurology·Mia Topsøe Mailand, Jette Lautrup Frederiksen
Sep 22, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Erik LandfeldtJan Hillert
Dec 10, 2016·Nature Reviews. Neurology·Tomas OlssonLars Alfredsson
Feb 14, 2017·Journal of Autoimmunity·Lamiae Grimaldi-BensoudaUNKNOWN PGRx-AD Study Group
Mar 20, 2018·Frontiers in Public Health·Chia-Ling KuoJames Grady
May 10, 2018·Annals of Neurology·Giulio DisantoClaudio Gobbi
Jul 7, 2018·Multiple Sclerosis : Clinical and Laboratory Research·José Ma WijnandsHelen Tremlett
Aug 20, 2018·Multiple Sclerosis and Related Disorders·Tanja HöggHelen Tremlett

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Citations

Dec 8, 2019·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Kerstin KlingGerd Burchard
Jan 11, 2020·Neurology. Neuroimmunology and Neuroinflammation·Alexander WinkelmannMicha Loebermann
Aug 1, 2019·Neurology·E Ann Yeh, Jennifer Graves
Jul 8, 2020·Practical Neurology·Saúl ReyesG Giovannoni
Jul 31, 2020·Neurology·Joep KillesteinBernhard Hemmer
Mar 13, 2021·Current Opinion in Neurology·Susana Otero-RomeroChristine Lebrun-Frénay
Jul 3, 2021·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Ismail Solmaz, Banu Anlar
Sep 9, 2021·Expert Review of Neurotherapeutics·Amin ZarghamiBruce V Taylor

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