A large French multicenter retrospective series of T1-T2N0 vocal cords carcinomas treated with exclusive irradiation

Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
A RobertG Calais

Abstract

The main objective of this study was to evaluate the 5-year efficacy of exclusive laryngeal radiotherapy without node prophylactic irradiation for localized cancers of the vocal cords. We retrospectively reviewed charts from 258 patients with T1-T2N0 glottic carcinoma irradiated from April 1987 to March 2015 in four France western centers, including pretreated patients. Toxicity was analyzed according to CTCAE v4.0 classification. The median follow-up was 50 months. The median age was 67 years with 87% men and 85.5% had T1 tumor. Five years overall survival was 77.5% (95% confidence interval [95% CI]: 71.4-83.5), 5 years local control was 86.8% (95% CI: 82.3-91.3), specific survival rate was 95% (95% CI: 92.2-97.9) and final laryngectomy-free survival was 87.5% (95% CI: 82.2-92.9). Most toxicities were grade 1 and 2. Grade 3 acute toxicity was 15.5% for the radiation laryngitis, 3.5% for radiodermatitis and 7.7% for dysphonia. Grade 3 chronic toxicity was 3.5% for dysphonia and there were two cases of tracheal stenosis treated by tracheotomy. Radiotherapy provides good results in local control of stage I and II vocal cords cancers as well as the toxicity level.

Citations

Sep 9, 2020·Head & Neck·William M MendenhallAlfio Ferlito
Jun 20, 2019·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·A Mucha-MałeckaK Małecki
Sep 8, 2021·Scientific Reports·Anna Mucha-MałeckaMaciej Modrzejewski

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