A large pheromone and receptor gene complex determines multiple B mating type specificities in Coprinus cinereus.

Genetics
S F O'SheaL A Casselton

Abstract

Pheromone signaling plays an essential role in the mating and sexual development of mushroom fungi. Multiallelic genes encoding the peptide pheromones and their cognate 7-transmembrane helix (7-TM) receptors are sequestered in the B mating type locus. Here we describe the isolation of the B6 mating type locus of Coprinus cinereus. DNA sequencing and transformation analysis identified nine genes encoding three 7-TM receptors and six peptide pheromone precursors embedded within 17 kb of mating type-specific sequence. The arrangement of the nine genes suggests that there may be three functionally independent subfamilies of genes each comprising two pheromone genes and one receptor gene. None of the nine B6 genes showed detectable homology to corresponding B gene sequences in the genomic DNA from a B3 strain, and each of the B6 genes independently alter B mating specificity when introduced into a B3 host strain. However, only genes in two of the B6 groups were able to activate B-regulated development in a B42 host. Southern blot analysis showed that these genes failed to cross-hybridize to corresponding genes in the B42 host, whereas the three genes of the third subfamily, which could not activate development in the B42 host, did c...Continue Reading

References

Jan 1, 1991·Annual Review of Biochemistry·H G DohlmanR J Lefkowitz
Feb 16, 1991·Biochimica Et Biophysica Acta·J W Dolan, S Fields
Apr 1, 1990·Trends in Biochemical Sciences·J A GlomsetC C Farnsworth
Jul 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·L M KunkelS A Latt
Mar 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D C HagenG F Sprague
Dec 1, 1988·Microbiological Reviews·I Herskowitz
Jan 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·Y KoltinG Simchen
Sep 1, 1995·Microbiological Reviews·G A CaldwellJ M Becker
Jul 19, 1994·Proceedings of the National Academy of Sciences of the United States of America·G Bakkeren, J W Kronstad
Jan 1, 1993·Annual Review of Genetics·J Kurjan
Mar 1, 1993·Molecular and Cellular Biology·T D Moore, J C Edman

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Citations

Sep 25, 2008·FEMS Microbiology Reviews·Chaoyang XueJoseph Heitman
Jul 4, 2008·Acta Microbiologica Et Immunologica Hungarica·Erika Kothe
Jun 29, 2004·Fungal Genetics and Biology : FG & B·Timothy Y JamesRytas Vilgalys
Sep 5, 2002·Nature Reviews. Genetics·Lorna Casselton, Miriam Zolan
May 10, 2005·Genetics·Meritxell RiquelmeAndrew J Brown
Aug 13, 2004·Proceedings. Biological Sciences·Duur K AanenRolf F Hoekstra
Jun 10, 2017·Microbiology Spectrum·Marco A CoelhoTatiana Giraud
Aug 12, 1999·Fungal Genetics and Biology : FG & B·E Kothe
Apr 5, 2002·Heredity·Lorna A Casselton
Apr 6, 2002·Proceedings. Biological Sciences·Anthony R IslesNicholas D Allen
Oct 31, 2002·Proceedings of the National Academy of Sciences of the United States of America·W Jason CummingsMiriam E Zolan
May 18, 2007·Annual Review of Microbiology·Liande LiKatherine A Borkovich
May 10, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Takashi Kamada
Nov 29, 2002·Eukaryotic Cell·Klaus B LengelerJoseph Heitman
Jun 6, 2000·Microbiology and Molecular Biology Reviews : MMBR·U Kües
Dec 13, 2002·Eukaryotic Cell·Hyojeong KimMary Anne Nelson
Aug 5, 2000·Fungal Genetics and Biology : FG & B·P J KostedJ E Sherwood
May 4, 2004·Nature Biotechnology·Diego MartinezDaniel Rokhsar
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·N LeeJ W Kronstad
Mar 2, 2010·Eukaryotic Cell·Marjatta Raudaskoski, Erika Kothe

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