A large proportion of fecal immunochemical test-positive participants in colorectal cancer screening is symptomatic

United European Gastroenterology Journal
Clasine M de KlerkEvelien Dekker

Abstract

Symptomatic invitees are advised not to participate in colorectal cancer (CRC) screening but to directly consult their general practitioner (GP), because fecal immunochemical test (FIT) sensitivity for cancer is not optimal. This recommendation may not always be followed in daily practice. We evaluated how many FIT-positive participants had CRC-related symptoms and whether the presence of symptoms was associated with the presence and location of CRC/advanced neoplasia. We prospectively collected data on CRC-related symptoms in all FIT-positive participants in the Dutch CRC screening program, referred to our endoscopy centers between 2014 and 2016, and evaluated whether symptoms were associated with detected CRC/advanced neoplasia at colonoscopy. Of 527 FIT-positive participants, 314 had advanced neoplasia, of which 41 had CRC. Overall, 246 (47%; 95% confidence interval (CI) 0.42-0.51) reported CRC-related symptoms. A change in bowel habits (odds ratio (OR) 2.86, CI 1.23-6.62) and visible blood in stool (OR 8.65, CI 2.34-32.0) were associated with the detection of CRC at colonoscopy. We did not observe significant associations between evaluated symptoms and advanced neoplasia. A large proportion of FIT-positive screening partici...Continue Reading

References

Aug 1, 1990·Gastroenterology·R S Sandler
Oct 16, 1999·The American Journal of Gastroenterology·S R MajumdarA T Evans
Aug 19, 2007·The British Journal of Surgery·M R ThompsonS Dodds
Sep 2, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Vincent DancourtJean Faivre
May 31, 2011·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Margaret AstinWilliam Hamilton
Apr 18, 2012·Scandinavian Journal of Gastroenterology·Kristin K AlexiusdottirJon G Jonasson
Aug 2, 2012·The American Journal of Gastroenterology·T R de WijkersloothE J Kuipers
Dec 6, 2012·The American Journal of Gastroenterology·Thomas R de WijkersloothEvelien Dekker
Jun 4, 2013·Scottish Medical Journal·J D SaldanhaR H Diament
Jun 12, 2013·International Journal of Colorectal Disease·Robert T PadwickMichael L Stellakis
Sep 21, 2013·The New England Journal of Medicine·Aasma ShaukatTimothy R Church
Jun 26, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Joaquín CubiellaJavier Fernández-Seara
Mar 1, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Martin C S WongJoseph J Y Sung
Jun 16, 2016·JAMA : the Journal of the American Medical Association·Jennifer S LinEvelyn P Whitlock
Nov 29, 2016·Gastroenterology·Esther Toes-ZoutendijkUNKNOWN Dutch National Colorectal Cancer Screening Working Group

❮ Previous
Next ❯

Citations

Dec 5, 2018·European Journal of Gastroenterology & Hepatology·Clasine M de KlerkEvelien Dekker
Jan 29, 2021·World Journal of Gastroenterology : WJG·Heather A SmithCraig Kuziemsky

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

World Journal of Gastroenterology : WJG
Vicent HernandezCOLONPREV study investigators
Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Sergio CrottaCarlo Senore
© 2022 Meta ULC. All rights reserved