A large-scale dataset of single and mixed-source short tandem repeat profiles to inform human identification strategies: PROVEDIt

Forensic Science International. Genetics
Lauren E AlfonseCatherine M Grgicak

Abstract

DNA-based human identity testing is conducted by comparison of PCR-amplified polymorphic Short Tandem Repeat (STR) motifs from a known source with the STR profiles obtained from uncertain sources. Samples such as those found at crime scenes often result in signal that is a composite of incomplete STR profiles from an unknown number of unknown contributors, making interpretation an arduous task. To facilitate advancement in STR interpretation challenges we provide over 25,000 multiplex STR profiles produced from one to five known individuals at target levels ranging from one to 160 copies of DNA. The data, generated under 144 laboratory conditions, are classified by total copy number and contributor proportions. For the 70% of samples that were synthetically compromised, we report the level of DNA damage using quantitative and end-point PCR. In addition, we characterize the complexity of the signal by exploring the number of detected alleles in each profile.

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Citations

Dec 4, 2019·BMC Bioinformatics·Slim KarkarDesmond S Lun
Nov 17, 2020·Forensic Science International. Genetics·Maarten KruijverJo-Anne Bright
Jan 2, 2021·Forensic Science International : Synergy·John M Butler, Sheila Willis
Feb 20, 2021·Forensic Science International. Genetics·Tacha HicksJohn Buckleton
Aug 14, 2018·Forensic Science International. Genetics·John M ButlerMichael D Coble
Jul 6, 2021·Forensic Science International. Genetics·Jakob ValtlCatherine M Grgicak
Jun 16, 2021·Forensic Science International. Genetics·Maarten KruijverJo-Anne Bright
Jul 21, 2021·Forensic Science International. Genetics·Catherine M GrgicakDesmond S Lun
Sep 24, 2021·Journal of Forensic Sciences·Kevin ChengJohn Buckleton
Oct 16, 2021·Journal of Forensic Sciences·Tim KalafutJohn Buckleton

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