PMID: 9525039Apr 3, 1998Paper

A large-scale model of some spinal reflex circuits

Biological cybernetics
D P Bashor

Abstract

This paper reports the development of a large-scale model of some spinal reflex circuitry, useful for studying the dynamic interactions among neuronal populations during simple behaviors. The included populations and properties of the neurons and terminals were derived from the literature, mainly on cat spinal cord. The model was conceived as a symmetrical controller of a pair of antagonistic muscles, within the behavioral domain of the stretch and Golgi-tendon-organ reflexes, and was scaled to include realistic numbers of motoneurons. Inputs to the model were fiber populations providing random synaptic drive to some of the populations and sensory stimuli appropriate for the reflexes. The resulting model contained roughly 2300 neurons in six pairs of populations. The total number of connections in the model was about 600,000, and individual postsynaptic potentials were small (0.1-0.6 mV). Model responses were calibrated by examination of their ability to reproduce known aspects of the reflexes. Published algorithms were used to construct the environment, which is easily expandable, in terms of membrane channels, neuronal geometry, and synaptic properties. The system was built to combine a system-level perspective of spinal circ...Continue Reading

Citations

May 29, 2008·Journal of Computational Neuroscience·Rogerio R L Cisi, André F Kohn
Mar 10, 2001·Current Opinion in Neurobiology·E E FetzY Prut
Feb 3, 1999·Annals of the New York Academy of Sciences·D P BashorL M Jordan
Sep 25, 2010·Journal of Computational Neuroscience·Jasper SchuurmansAlfred C Schouten
May 16, 2007·Journal of Computational Neuroscience·Arno H A StienenFrans C T van der Helm
Dec 3, 2008·Experimental Brain Research·Jasper SchuurmansFrans C T van der Helm
Nov 25, 2011·Journal of Biomechanics·Winfred MuggeFrans C T van der Helm
Sep 24, 2015·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Manish SreenivasaYoshihiko Nakamura
Sep 30, 2016·Journal of Computational Neuroscience·Bernard Grandjean, Marc A Maier
Aug 2, 2013·Journal of Neurophysiology·Patrick A ForbesJean-Sébastien Blouin
Dec 1, 2017·Journal of Neurophysiology·Anton Sobinov, Sergiy Yakovenko

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