A large-scale perspective on stress-induced alterations in resting-state networks

Scientific Reports
Adi Maron-KatzRon Shamir

Abstract

Stress is known to induce large-scale neural modulations. However, its neural effect once the stressor is removed and how it relates to subjective experience are not fully understood. Here we used a statistically sound data-driven approach to investigate alterations in large-scale resting-state functional connectivity (rsFC) induced by acute social stress. We compared rsfMRI profiles of 57 healthy male subjects before and after stress induction. Using a parcellation-based univariate statistical analysis, we identified a large-scale rsFC change, involving 490 parcel-pairs. Aiming to characterize this change, we employed statistical enrichment analysis, identifying anatomic structures that were significantly interconnected by these pairs. This analysis revealed strengthening of thalamo-cortical connectivity and weakening of cross-hemispheral parieto-temporal connectivity. These alterations were further found to be associated with change in subjective stress reports. Integrating report-based information on stress sustainment 20 minutes post induction, revealed a single significant rsFC change between the right amygdala and the precuneus, which inversely correlated with the level of subjective recovery. Our study demonstrates the v...Continue Reading

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Citations

Apr 4, 2017·Human Brain Mapping·Eti Ben SimonTalma Hendler
Nov 22, 2017·Cerebral Cortex·Viola BorchardtSimone Grimm
Oct 5, 2019·The Journal of Clinical Endocrinology and Metabolism·Liesa IlgNina Alexander
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Oct 2, 2020·Cognitive, Affective & Behavioral Neuroscience·Heather E DarkDavid C Knight
Jan 28, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Neir EshelAmit Etkin

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