A large-scale population study of early life factors influencing left-handedness

Scientific Reports
Carolien G F de KovelClyde Francks

Abstract

Hand preference is a conspicuous variation in human behaviour, with a worldwide proportion of around 90% of people preferring to use the right hand for many tasks, and 10% the left hand. We used the large cohort of the UK biobank (~500,000 participants) to study possible relations between early life factors and adult hand preference. The probability of being left-handed was affected by the year and location of birth, likely due to cultural effects. In addition, hand preference was affected by birthweight, being part of a multiple birth, season of birth, breastfeeding, and sex, with each effect remaining significant after accounting for all others. Analysis of genome-wide genotype data showed that left-handedness was very weakly heritable, but shared no genetic basis with birthweight. Although on average left-handers and right-handers differed for a number of early life factors, all together these factors had only a minimal predictive value for individual hand preference.

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Citations

Apr 6, 2019·Genes, Brain, and Behavior·Amaia Carrion-CastilloClyde Francks
Aug 14, 2019·The European Journal of Neuroscience·Lyam M BaileyAaron J Newman
May 19, 2020·Human Brain Mapping·Xiang-Zhen KongClyde Francks
Mar 1, 2020·Scientific Reports·Merel C PostemaClyde Francks
Apr 14, 2019·Scientific Reports·Carolien G F de Kovel, Clyde Francks
Sep 19, 2020·International Journal of Environmental Research and Public Health·Danilo BondiClaudio Robazza
Sep 4, 2020·Scientific Reports·Julian PackheiserSebastian Ocklenburg
Apr 3, 2020·Physiological Reviews·Onur GüntürkünSebastian Ocklenburg
Dec 2, 2020·Scientific Reports·Gesa BerretzSebastian Ocklenburg
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Oct 10, 2021·Developmental Science·Grégoire Boulinguez-AmbroiseAdrien Meguerditchian

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Methods Mentioned

BETA
genotyping

Software Mentioned

stats
Rstudio
glm
GREML
GCTA
LMM
fastPCA
BOLT
TRAIT
R

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