A large series, resection controlled study to assess the value of radial EUS in restaging gastroesophageal cancer following neoadjuvant chemotherapy

Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus
S MesenasJ Meenan

Abstract

The true value of endoscopic ultrasound (EUS) post-neoadjuvant chemotherapy for esophageal carcinoma is not established. Superior loco-regional detail may yield useful staging and prognostic information but information on its accuracy, as compared with computed tomography (CT), remains undefined and limited by small study size. We prospectively studied 109 patients with gastroesophageal cancer; 99 of whom were undergoing surgery. All had EUS and helical CT imaging before and after neoadjuvant chemotherapy and the results were compared with pathological staging of resected specimens. Tumor response was assessed by the reduction in maximal tumor depth at EUS and correlated with patient survival. There was no difference in T and N stage accuracies between EUS and CT following neoadjuvant chemotherapy. manova showed a reduction in maximal tumor depth by > 50% at EUS to be associated with longer survival (relative risk = 0.48, P < 0.05). EUS responders had a median survival of 38 months compared to 30 months for non-responders (P < 0.05). The identification of lymphadenopathy at radial EUS was not predictive of survival. This large series study demonstrates the staging accuracy of CT and non-biopsy EUS in the setting of neoadjuvant ...Continue Reading

References

Nov 1, 1994·Endoscopy·H J DittlerG R Siewert
Jan 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B A BatesJ E Tepper
Aug 15, 1996·The New England Journal of Medicine·T N WalshT P Hennessy
Oct 23, 1997·Chest·A A ForastiereL Kleinberg
Aug 26, 1998·Gastrointestinal Endoscopy·G IsenbergM V Sivak
Sep 11, 1999·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·D J BowreyP D Carey
Feb 24, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S G UrbaM Strawderman
Jun 7, 2002·Gut·W H AllumUNKNOWN British Association of Surgical Oncology
Jun 7, 2002·Lancet·UNKNOWN Medical Research Council Oesophageal Cancer Working Group
Jan 16, 2004·Gastroenterology·Enrique Vazquez-SequeirosAlan R Zinsmeister

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Citations

Sep 12, 2009·Best Practice & Research. Clinical Gastroenterology·M Polkowski
Jul 16, 2008·Current Opinion in Gastroenterology·Laith H JamilMichael B Wallace
May 26, 2009·Current Opinion in Gastroenterology·Thomas J Savides
Jul 26, 2008·Scandinavian Journal of Gastroenterology·Evangelos Kalaitzakis, John Meenan
Sep 3, 2013·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Ulrike HegerKatja Ott
May 5, 2011·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·W-L ChangB-S Sheu
Jan 22, 2015·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·C YipV Goh
Sep 2, 2017·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·W BohleW G Zoller

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