A large study reveals no association between APOE and Parkinson's disease.

Neurobiology of Disease
Monica FederoffAndrew B Singleton

Abstract

Research focusing on the role of APOE in Parkinson's disease (PD) has been largely inconclusive, creating a broad discrepancy in association studies. To elucidate the role of APOE alleles in PD risk by studying a large sample size and controlling for population substructure. In total, 3465 case and control samples were genotyped, obtained from the NINDS Neurogenetics repository. No significant differences in ε4 dosages exist between PD cases and controls. The frequency of ε4 carriers differed slightly between cases and controls at 24% (580/2412) and 26% (270/1053), respectively. Likewise, mean dosages of APOE ε2 were not significantly different between cases and controls. APOE ε2 carriers were observed at a frequency of 13.6% (329/2412) among cases and 15% (158/1053) among controls. Logistic regression models evaluating PD as possibly associated with ε4 or ε2 carrier status and allele dosages yielded no significant results. The mean MMSE score among all PD cases was 28.35 (SD = 2.58) and memory loss was reported in only 11.9% (105/879) of cases. Linear regression models comparing MMSE scores as predicted by ε4 or ε2 carrier status and allele dosages were not significant. There is no association between APOE epsilon alleles and ...Continue Reading

References

Mar 3, 2004·Molecular Interventions·K R BalesS M Paul
Nov 23, 2006·Neuroscience Letters·Daniel D BuchananGeorge D Mellick
Mar 27, 2009·Journal of Geriatric Psychiatry and Neurology·Martin Wilhelm KurzGuido Alves
May 12, 2010·Acta Neurologica Scandinavica·H VefringUNKNOWN Norwegian ParkWest Study group

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Citations

Jun 26, 2013·Acta neurologica Belgica·Manuel MulthammerHans-Hermann Klünemann
Jan 9, 2013·Nature Reviews. Neurology·Chia-Chen LiuGuojun Bu
Aug 1, 2014·Brain : a Journal of Neurology·Cristina NombelaRoger A Barker
Nov 1, 2013·BioMed Research International·Michele L GregórioDorotéia R S Souza
Feb 15, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Hung-Jin HuangCalvin Yu-Chian Chen
Feb 18, 2015·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Monica FederoffAndrew Singleton
Jun 1, 2016·Frontiers in Psychiatry·Lucy M Collins, Caroline H Williams-Gray
Aug 19, 2014·Neurobiology of Disease·David A HottmanLing Li
Mar 4, 2017·Nature Reviews. Neurology·Dag AarslandClive Ballard
Dec 3, 2014·Neurobiology of Aging·Mike A NallsUNKNOWN Parkinson's Disease meta-analysis consortium
Jun 28, 2017·Journal of the International Neuropsychological Society : JINS·Denise R LaBelleSarah J Banks
Feb 22, 2017·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·E S Fagan, L Pihlstrøm
Sep 8, 2017·Molecular Neurobiology·Veena TheendakaraRammohan V Rao
Jan 8, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Shraddha SapkotaRichard Camicioli
Sep 27, 2018·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·K A SenkevichS N Pchelina
Oct 27, 2017·Chinese Medical Journal·Lin LiMao-Ting Yuan
Apr 9, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Cornelis BlauwendraatUNKNOWN International Parkinson's Disease Genomics Consortium (IPDGC)
Jul 14, 2019·BioFactors·Afsane BahramiAmirhossein Sahebkar
Apr 24, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Glenda M HallidayCharles H Adler
Nov 8, 2019·Experimental Neurobiology·Uram JinSang Myun Park
Jan 13, 2016·Journal of Parkinson's Disease·Daniel LindqvistOskar Hansson
Sep 5, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Judy PotashkinConnie Marras
Jun 28, 2019·Neurology·Carmel Armon, Bryan J Traynor
Mar 19, 2016·Oncotarget·Sandeep Vasant More, Dong-Kug Choi
Sep 12, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·María Teresa PeriñánPablo Mir
Aug 14, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Mike A NallsUNKNOWN Parkinson's Progression Marker Initiative (PPMI) investigators
Jul 12, 2017·Journal of Molecular Neuroscience : MN·Fatemeh Nouri Emamzadeh
Sep 11, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Hirotaka IwakiMike A Nalls
Oct 13, 2017·Frontiers in Neurology·Lijun ZhangXuemei Huang
Aug 12, 2018·Current Neurology and Neuroscience Reports·Tatiana OrmeJose Bras
Aug 1, 2019·Acta Neuropathologica Communications·Benjamin R SmithKaren H Ashe
Aug 2, 2019·Nature Reviews. Neurology·Yu YamazakiGuojun Bu
Feb 7, 2020·Science Translational Medicine·Albert A DavisDavid M Holtzman
Apr 26, 2018·Frontiers in Neuroscience·Laura IbanezBruno A Benitez
Feb 8, 2021·Neuromolecular Medicine·Jun Yup LeeAnthony S Don
Nov 6, 2020·Molecular Neurodegeneration·Zonghua LiGuojun Bu
Mar 2, 2021·Journal of Alzheimer's Disease : JAD·Tamara ShinerNoa Bregman
Feb 23, 2021·Frontiers in Neurology·Jon-Anders TunoldLasse Pihlstrøm
Apr 11, 2021·Scientific Reports·Sungyang JoSun Ju Chung

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