A laser micromachined probe for recording multiple field potentials in the thalamus

Journal of Neuroscience Methods
You-Yin ChenFu-Shan Jaw

Abstract

Multichannel recording provides integral information about electrical brain activities at one instant in time. In this study, multielectrode probes were fabricated to record the thalamic field potentials (FPs) responding to the electrical stimulation of nerve at the rat tail. At first, the number of sweeps used to form the evoked FP average and the spatial sampling density were determined by using cross-correlation functions, which were then statistically analyzed. The difference was significant at P < 0.05, if the number of sweeps for averaging was more than 50 and the spatial interval between two consecutive recording sites was less than 50 microm in the anteroposterior, mediolateral and ventrodorsal directions. The responsive area was distributed vertically in the thalamus (ventral posterior lateral (VPL) nucleus); therefore, the recording sites were arranged in one linear array. Sixteen recording sites, which were 50 microm apart from each other, were distributed in the ventrodorsal direction. A 16-channel silicon probe was fabricated by using a standard photolithography process and laser micromachining techniques. The probe provides capabilities to record multiple thalamic evoked FPs and multiunit activities simultaneously.

References

May 1, 1975·IEEE Transactions on Bio-medical Engineering·K D Wise, J B Angell
Jan 1, 1992·Annals of Biomedical Engineering·P J Rousche, R A Normann
Jun 1, 1989·Journal of Neuroscience Methods·G BuzsàkiF H Gage
Feb 1, 1986·IEEE Transactions on Bio-medical Engineering·S L BeMentK L Drake
Jul 1, 1973·IEEE Transactions on Bio-medical Engineering·A StarrJ Csongradi
Jul 1, 1970·IEEE Transactions on Bio-medical Engineering·K D WiseA Starr
Jul 1, 1983·Pain·Eric H Chudler, Willie K Dong
Dec 1, 1994·Circulation·B TaccardiY Vyhmeister
Apr 1, 1994·IEEE Transactions on Bio-medical Engineering·T AkinR M Bradley
Apr 1, 1994·IEEE Transactions on Bio-medical Engineering·J F HetkeD J Anderson
May 16, 1997·Journal of Neuroscience Methods·R M BradleyK Najafi

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Citations

May 27, 2005·Journal of Neuroscience Methods·Chia-Nan Chien, Fu-Shan Jaw
Aug 26, 2006·Nature Clinical Practice. Neurology·William S Anderson, Frederick A Lenz
Sep 12, 2017·Journal of Integrative Neuroscience·Amber L Harris BozerAi-Ling Li

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