A lethal disease model for New World hantaviruses using immunosuppressed Syrian hamsters

PLoS Neglected Tropical Diseases
Valentijn VergotePiet Maes

Abstract

Hantavirus, the hemorrhagic causative agent of two clinical diseases, is found worldwide with variation in severity, incidence and mortality. The most lethal hantaviruses are found on the American continent where the most prevalent viruses like Andes virus and Sin Nombre virus are known to cause hantavirus pulmonary syndrome. New World hantavirus infection of immunocompetent hamsters results in an asymptomatic infection except for Andes virus and Maporal virus; the only hantaviruses causing a lethal disease in immunocompetent Syrian hamsters mimicking hantavirus pulmonary syndrome in humans. Hamsters, immunosuppressed with dexamethasone and cyclophosphamide, were infected intramuscularly with different New World hantavirus strains (Bayou virus, Black Creek Canal virus, Caño Delgadito virus, Choclo virus, Laguna Negra virus, and Maporal virus). In the present study, we show that immunosuppression of hamsters followed by infection with a New World hantavirus results in an acute disease that precisely mimics both hantavirus disease in humans and Andes virus infection of hamsters. Infected hamsters showed specific clinical signs of disease and moreover, histological analysis of lung tissue showed signs of pulmonary edema and inflam...Continue Reading

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Citations

Jul 16, 2020·The Journal of General Virology·Stuart D DowallRoger Hewson
Jun 6, 2018·Frontiers in Cellular and Infection Microbiology·Marcelo L M PereiraSabrina Epiphanio
Aug 28, 2020·Frontiers in Bioengineering and Biotechnology·Michael Hilary D'Souza, Trushar R Patel
Apr 2, 2021·Frontiers in Cellular and Infection Microbiology·Valentijn VergotePiet Maes

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Methods Mentioned

BETA
sedation
biopsy
GTPases

Software Mentioned

GraphPad Prism

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