PMID: 8581321Jan 1, 1995Paper

A lethal protein toxin (toxin-PC) from the Indian catfish (Plotosus canius, Hamilton) venom

Natural Toxins
B AuddyA Gomes

Abstract

Isolation and purification of a lethal protein toxin from the Indian catfish Plotosus canius, Hamilton, venom is described. The purification procedure involved ammonium sulfate precipitate of crude venom followed by DEAE-ion exchange chromatography. The purified toxin (toxin-PC) was homogeneous on one-dimensional PAGE and PAS-negative, and had a molecular weight 15 Kd. Toxin-PC was lethal (LD50 225 micrograms/kg, intravenous, in mice) and cardiotoxic, having neuromuscular blocking activity. Toxin-PC produced cardiac arrest on isolated toad and guinea pig hearts. Prior administration of atropine and propanolol failed to counteract toxin activity on isolated heart preparations. On isolated chick biventer cervicis, toxin-PC produced total blockage of electrically-induced twitch response without affecting carbachol- and acetylcholine-induced contraction. The tension developed by the muscle was Ca++ ion-dependent. Neuromuscular blocking time was reduced when K+ ion concentration was increased in the medium. Antiserum raised against toxin-PC failed to antagonize lethal activity of toxin-PC in mice. Toxin-PC probably represents a major toxic component of catfish venom (P. canius), and was responsible for the pathophysiological changes.

References

Jul 28, 1972·Science·E Habermann
Dec 28, 1964·Annals of the New York Academy of Sciences·B J DAVIS
Jan 1, 1948·Acta Pathologica Et Microbiologica Scandinavica·O OUCHTERLONY

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Citations

Aug 8, 2002·Toxicon : Official Journal of the International Society on Toxinology·Jarrod E Church, Wayne C Hodgson
May 6, 2015·Toxins·Rebekah Ziegman, Paul Alewood
Aug 16, 2011·Toxicon : Official Journal of the International Society on Toxinology·Saki TamuraKazuo Shiomi
May 8, 2016·Toxicon : Official Journal of the International Society on Toxinology·Helena L GomesSuely G Figueiredo

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