A lethal synergy induced by phellinus linteus and camptothecin11 in colon cancer cells

Oncotarget
Tianqi YuChangyan Chen

Abstract

Side effects of anti-cancer drugs are always challenging for effective cancer treatments. The polysaccharides extracted fromPhellinus linteus(PLGL) have been widely used in treating cancers. However, the mechanism by which PLGL antagonizes cancerous growth has not been fully investigated. The current study demonstrated that human colon cancer HCT116 and HT29 cells became highly susceptible to cell death when being co-treated with PLGL and low dose of camptothecin11 (CPT11, a topoisomerase inhibitor-based drug), the efficacy of which was comparable as that generated by the high dose of CPT11. However, the co-treatment, unlike high doses of CPT11, was not cytotoxic to the control immortalized colon Caco-2 cells. The co-treatment caused high percentages of the colon cancer cells to accumulate in S phase of the cell cycle, which was also seen in the same cells received the high dose of CPT11 treatment. Chk1 was phosphorylated, and then rapidly degraded in the cancer cells treated with the high dose of CPT11 or co-treatment, but not in the cells treated with PLGL alone or low doses of CPT11. PLGL appeared enhancing CPT11 inhibitory effect on topoisomerase, and Chk1 degradatopm in the cancer cells. Furthermore, cyclin E (clnE) became...Continue Reading

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Citations

May 19, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wenhua ChenLingchuan Xu

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Methods Mentioned

BETA
gel filtration
ubiquitination
xenograft
flowcytometry
transfection

Software Mentioned

Fit
Cell
PLGL

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