A library screening approach identifies naturally occurring RNA sequences for a G-quadruplex binding ligand

Chemical Communications : Chem Comm
Gayan Mirihana ArachchilageSoumitra Basu

Abstract

An RNA G-quadruplex library was synthesised and screened against kanamycin A as the ligand. Naturally occurring G-quadruplex forming sequences that differentially bind to kanamycin A were identified and characterized. This provides a simple and effective strategy for identification of potential intracellular G-quadruplex targets for a ligand.

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Citations

Apr 17, 2015·Organic & Biomolecular Chemistry·Prachi AgarwalaSouvik Maiti
Dec 26, 2016·Nucleic Acids Research·Anne Cammas, Stefania Millevoi

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