A light and electron microscopic study of recurrent granular dystrophy of the cornea

American Journal of Ophthalmology
B L JohnsonG W Zaidman

Abstract

Light and electron microscopic studies in three cases of recurrent granular dystrophy with corneal epithelial involvement showed intracellular rod and trapezoidal crystalline granules characteristic of granular dystrophy. Small intraepithelial cytoplasmic granules were rimmed by 15-nm particles, while larger deposits were often membrane-bound. The granules were closely associated with tonofilaments. There were ultrastructural similarities to keratohyaline. Extracellular granules were often intermixed with cytoplasmic organelles of disintegrated squamous epithelial cells. There was no evidence of a subepithelial pannus. These findings suggest an epithelial origin of the granular dystrophic deposits in these recurrent cases.

References

Jul 1, 1978·American Journal of Ophthalmology·S L LempertS I Brown
Jan 15, 1979·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·H Witschel, R Sundmacher
Jan 1, 1975·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·T IwamotoA G DeVoe
Jun 1, 1970·The British Journal of Ophthalmology·R C Tripathi, A Garner
Dec 1, 1969·The British Journal of Ophthalmology·A Garner

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Citations

Jan 1, 1983·American Journal of Ophthalmology·G K KlintworthP S Binder
Dec 17, 2002·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·H Barry Collin, Peter L Hendicott
Sep 15, 1999·Ophthalmology·L P WernerG Renard
Nov 28, 2015·Progress in Retinal and Eye Research·Kyung Eun HanEung Kweon Kim
Apr 7, 2016·Indian Journal of Ophthalmology·Varsha M RathiVirender S Sangwan
Nov 1, 1996·Australian and New Zealand Journal of Ophthalmology·R B VajpayeeH R Taylor
Oct 25, 2003·Cornea·Anthony J AldaveDavid G Hwang
Aug 1, 1996·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·G Wollensak, H Witschel
Jun 20, 2006·Cornea·Martine FrisingSusanne Pitz
Nov 29, 2007·Cornea·Sepehr FeiziShahin Yazdani
Jan 15, 2014·Optometry and Vision Science : Official Publication of the American Academy of Optometry·David P Roncone
Jul 20, 2002·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·H Witschel
Oct 1, 1985·Acta Ophthalmologica·H U Møller, N Ehlers
Jan 1, 1982·Current Eye Research·M M Rodrigues, P G Robey
Feb 1, 1990·Acta Ophthalmologica·H U Møller, A E Ridgway
Jul 27, 2001·Progress in Retinal and Eye Research·S KinoshitaK Okubo
Jun 5, 2004·Journal français d'ophtalmologie·C-F Schmitt-BernardA Argilès

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