A light-controllable specific drug delivery nanoplatform for targeted bimodal imaging-guided photothermal/chemo synergistic cancer therapy

Acta Biomaterialia
Yuan GuoZhao-Xia Wang

Abstract

Breast cancer is a severe threat to the health and lives of women due to its difficult early diagnosis and the unsatisfactory therapeutic efficacy of breast cancer treatments. The development of theranostic strategies to combat breast cancer with high accuracy and effectiveness is therefore urgently needed. In this study, we describe a near-infrared (NIR) light-controllable, targeted and biocompatible drug delivery nanoplatform (PFH-PTX@PLGA/SPIO-Her) for photoacoustic (PA)/ultrasound (US) bimodal imaging-guided photothermal (PTT)/chemo synergistic cancer therapy of breast cancer. Carboxyl-modified PEGylated poly (lactic-co-glycolic acid) (PLGA-PEG-COOH) constituted the skeleton of the nanoplatform. Especially, the antibody Herceptin was modified onto the surface of nanoplatform for active HER2-targing to facilitate the tumor accumulation of the nanoplatform. The encapsulated superparamagnetic iron oxide (SPIO) nanoparticles could be employed as an excellent PA imaging agent to guide tumor therapy. When exposed to NIR light, the SPIO also could transform NIR light into thermal energy for photothermal ablation of tumor. The NIR-induced thermal effect subsequently triggered the optical droplet vaporization (ODV) of perfluorohexan...Continue Reading

Citations

Aug 31, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Xuhong ZhaoShengsong Tang
Jan 11, 2019·Pharmaceutics·Catarina Oliveira SilvaCatarina Reis
Jun 12, 2019·Contrast Media & Molecular Imaging·Sara GargiuloMarcello Mancini
Mar 2, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Junya LuSiling Wang
Mar 24, 2021·Journal of Nanobiotechnology·Xiajing ChenJie Tian
Jun 18, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Yan ZhangKun Zhang
Jun 25, 2021·Chemistry : a European Journal·Sangni JiangXifei Yu
Nov 5, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Mathieu CianconeFranck Camerel
Sep 21, 2019·ACS Nano·Lichan ChenJibin Song

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