A Light-Controlled Release System Based on Molecular Recognition of Cyclodextrins

Macromolecular Rapid Communications
Isaac Eng Ting LeeAkira Harada

Abstract

This Communication describes a new light-controlled release system based on molecular recognition of cyclodextrins. Azobenzene (Azo) residue is employed as a photoresponsive guest residue because it can switch the partner from α-cyclodextrin (αCD) to β-cyclodextrin (βCD) by irradiation with UV light. Poly(sodium acrylate)s possessing αCD, βCD, and Azo residues (pAαCD, pAβCD, and pAAzo, respectively) are mixed in aqueous solutions to form aggregates through the formation of inclusion complexes of Azo with αCD and/or βCD. A chemical cargo, 1-pyrenemethylammonium chloride (PyMA), is contained in the aggregates, and its release behavior is investigated by dialysis experiments under UV irradiation. These data indicate that the amount of PyMA released for the pAαCD/pAβCD/pAAzo ternary mixture is approximately three times as high as those for the pAαCD/pAAzo and pAβCD/pAAzo binary mixtures because of the light-controlled rearrangement of inclusion complexes.

References

Jun 6, 2000·Advanced Drug Delivery Reviews·F Hirayama, K Uekama
Dec 18, 2001·Advanced Drug Delivery Reviews·Y Qiu, K Park
Jan 5, 2002·Advanced Drug Delivery Reviews·Akihiko Kikuchi, Teruo Okano
Jun 6, 2002·Drug Discovery Today·Piyush GuptaSanjay Garg
Nov 28, 2006·Advanced Drug Delivery Reviews·Dirk Schmaljohann
Jun 19, 2007·International Journal of Pharmaceutics·Satyakam PatnaikK C Gupta
Jun 22, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·C J F RijckenC F van Nostrum
Feb 12, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Srinivas GantaMansoor Amiji
Jan 7, 2009·Biomacromolecules·Fenghua MengJan Feijen
Mar 16, 2011·Biomacromolecules·Laura A WellsHeather Sheardown
Jul 13, 2011·Advanced Drug Delivery Reviews·Itsuro TomatsuAlexander Kros
Jan 5, 2012·Nature Communications·Hiroyasu YamaguchiAkira Harada
Mar 6, 2012·Advanced Drug Delivery Reviews·Nadezda FominaAdah Almutairi
Mar 24, 2012·Chemical Society Reviews·Piaoping YangJun Lin
Oct 24, 2013·Nature Materials·Simona MuraPatrick Couvreur
Aug 20, 2014·Accounts of Chemical Research·Akshaya Bansal, Yong Zhang
Sep 17, 2014·Biomacromolecules·Congcong ZhuChristopher J Bettinger
Mar 15, 2015·ACS Applied Materials & Interfaces·Hsuan-Chin WangJoshua S Katz

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