A LIN28B Tumor-Specific Transcript in Cancer

Cell Reports
Weijie GuoShenglin Huang

Abstract

The diversity and complexity of the cancer transcriptome may contain transcripts unique to the tumor environment. Here, we report a LIN28B variant, LIN28B-TST, which is specifically expressed in hepatocellular carcinoma (HCC) and many other cancer types. Expression of LIN28B-TST is associated with significantly poor prognosis in HCC patients. LIN28B-TST initiates from a de novo alternative transcription initiation site that harbors a strong promoter regulated by NFYA but not c-Myc. Demethylation of the LIN28B-TST promoter might be a prerequisite for its transcription and transcriptional regulation. LIN28B-TST encodes a protein isoform with additional N-terminal amino acids and is critical for cancer cell proliferation and tumorigenesis. Our findings reveal a mechanism of LIN28B activation in cancer and the potential utility of LIN28B-TST for clinical purposes.

Citations

Jun 8, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Qiupeng ZhengShenglin Huang
Nov 13, 2020·Nucleic Acids Research·Qin LiShenglin Huang
May 17, 2021·Trends in Cancer·Yangjun WuShengli Li

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