A linear molecule with two large inverted repeats: the mitochondrial genome of the stramenopile Proteromonas lacertae.

Genome Biology and Evolution
Vicente Pérez-BrocalC Graham Clark

Abstract

Mitochondrial evolution has given rise to a complex array of organelles, ranging from classical aerobic mitochondria to mitochondrial remnants known as hydrogenosomes and mitosomes. The latter are found in anaerobic eukaryotes, and these highly derived organelles often retain only scant evidence of their mitochondrial origins. Intermediate evolutionary stages have also been reported as facultatively or even strictly anaerobic mitochondria, and hydrogenosomes that still retain some mitochondrial features. However, the diversity among these organelles with transitional features remains rather unclear and barely studied. Here, we report the sequence, structure, and gene content of the mitochondrial DNA of the anaerobic stramenopile Proteromonas lacertae. It has a linear genome with a unique central region flanked by two identical large inverted repeats containing numerous genes and "telomeres" with short inverted repeats. Comparison with the organelle genome of the strictly anaerobic human parasite Blastocystis reveals that, despite the close similarity of the sequences, features such as the genome structure display striking differences. It remains unclear whether the virtually identical gene repertoires are the result of converge...Continue Reading

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Citations

Mar 8, 2011·Molecular Biology and Evolution·Rob M de GraafJohannes H P Hackstein
Jan 27, 2011·Nucleic Acids Research·Matus ValachJozef Nosek
Feb 9, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Liang MaJoseph A Kovacs
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Sep 2, 2011·EMBO Reports·Michael W Gray
Oct 26, 2016·Current Biology : CB·Ryan M R GawrylukAndrew J Roger
Apr 30, 2017·Genome Biology and Evolution·Jiwon YangAndrew J Roger

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Datasets Mentioned

BETA
GU563431
GU002153

Methods Mentioned

BETA
PCR
PCRs

Software Mentioned

Phyml
Blast

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