A link among schizophrenia, diabetes, and asthma: Role of Ca2+ /cAMP signaling

Brain Circulation
Leandro Bueno Bergantin

Abstract

Asthma has been associated with an increased risk for developing schizophrenia. In addition, schizophrenia has been associated with an increased risk for developing type 2 diabetes mellitus, resulting in an elevated cardiovascular risk and in a limited life expectancy. It is well discussed that dysregulations related to Ca2+ signaling could link these diseases, in addition to cAMP signaling pathways. Thus, revealing this interplay among schizophrenia, diabetes, and asthma may provide novel insights into the pathogenesis of these diseases. Publications involving Ca2+ and cAMP signaling pathways, schizophrenia, diabetes, and asthma (alone or combined) were collected by searching PubMed and EMBASE. Both Ca2+ and cAMP signaling pathways (Ca2+/cAMP signaling) control the release of neurotransmitters and hormones, in addition to airway smooth muscle contractility, then dysregulations of these cellular processes may be involved in these diseases. Taking into consideration, the experience of our group in this field, this narrative review debated the involvement of Ca2+/cAMP signaling in this link among schizophrenia, diabetes, and asthma, including its pharmacological implications.

References

Jan 25, 1985·The American Journal of Cardiology·C H Fanta
Jan 30, 2002·Diabetes·Troitza K Bratanova-TochkovaGeoffrey W G Sharp
Oct 31, 2003·The New England Journal of Medicine·Robert Freedman
Jan 28, 2004·Annual Review of Psychology·Elaine WalkerKaren M Hochman
May 28, 2004·The Journal of Clinical Psychiatry·J Steven LambertiMarci B Dietz
Mar 4, 2006·The American Journal of Psychiatry·William W EatonPreben Bo Mortensen
Jul 28, 2006·Psychiatric Services : a Journal of the American Psychiatric Association·Leslie CitromeDavid Martello
Oct 3, 2006·Journal of Theoretical Biology·Simone GuptaSamir K Brahmachari
Oct 9, 2007·Acta Psychiatrica Scandinavica·S LeuchtN Sartorius
Nov 7, 2007·CNS Spectrums·Christoph U Correll
Nov 9, 2007·European Archives of Psychiatry and Clinical Neuroscience·Jaana SuvisaariAntti Reunanen
Sep 26, 2009·Seminars in Immunopathology·Britta Engelhardt, Lydia Sorokin
Dec 3, 2009·Psychiatric Services : a Journal of the American Psychiatric Association·Ryan C BellDebra Srebnik
Sep 14, 2010·Schizophrenia Research·P I Lin, A R Shuldiner
Oct 1, 2010·Clinical Schizophrenia & Related Psychoses·Jeanette M JerrellAvnish Tripathi
Feb 9, 2011·Archives of General Psychiatry·Debra L Foley, Katherine I Morley
Mar 8, 2011·European Psychiatry : the Journal of the Association of European Psychiatrists·S ViertiöJ Suvisaari
May 17, 2011·European Psychiatry : the Journal of the Association of European Psychiatrists·D SchoepfR Heun
Dec 15, 2011·Obesity Facts·Evert J MookhoekAnton J M Loonen
Mar 24, 2012·The British Journal of Psychiatry : the Journal of Mental Science·Shaw-Ji ChenHui-Ju Tsai
Mar 24, 2012·Diabetes·Guanlan XuAnath Shalev
May 29, 2012·Pulmonary Pharmacology & Therapeutics·Charlotte K BillingtonSatoru Ito
Sep 14, 2012·Upsala Journal of Medical Sciences·Anders Tengholm
Apr 1, 2014·The Application of Clinical Genetics·Berit Kerner
Jun 4, 2014·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Debra L FoleyCherrie A Galletly
Aug 26, 2014·Journal of Psychosomatic Research·Per WändellAxel C Carlsson
Jan 25, 2016·Current Diabetes Reports·Jaana SuvisaariOuti Mantere
Apr 28, 2018·Schizophrenia Bulletin·Jennie G Pouget
May 14, 2018·Psychiatrikē = Psychiatriki·V MamakouV Kontaxakis
Jan 15, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Leandro Bueno Bergantin
Jul 12, 2019·Current Diabetes Reviews·Leandro B Bergantin

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