A link between cold environment and cancer

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Ankit SharmaChandi C Mandal

Abstract

Many risk factors such as smoking and change of life style have been shown to promote genetic and adaptive epigenetic changes responsible for tumorigenesis. This study brings environmental temperature as a cancer causing factor to light. The cancer mortality rate (CMR) of a country was correlated with 17 different variables. Multivariate analysis of a total of 188 countries found that the average annual temperature (AAT) of a country might have a significant contribution to cancer death when compared with other factors such as alcohol and meat consumption. Univariate analysis found a negative correlation between AAT and CMR. All these countries were categorized into three temperature zones (zone I, -2 to 11.5 °C; number of countries, 38; zone II, 11.6 to 18.6 °C; number of countries, 32; and zone III, 18.7 to 30 °C; number of countries, 118). Out of the top-most 50 countries having the highest CMR, 26 (68.42 %), 10 (31.25 %), and 14 (11.66 %) belong to zone I, zone II, and zone III, respectively. Out of the least 50 countries having the lowest CMR, 1 (2.63 %), 4 (12.5 %), and 45 (37.5 %) belong to zone I, zone II, and zone III, respectively. CMR is low in those countries situated near to the Torrid zone (33(°) N to 23.5(°)S), b...Continue Reading

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Citations

Jan 23, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Chandi C MandalJames A Radosevich
Oct 13, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ankit SharmaChandi C Mandal
Apr 4, 2019·BMC Cancer·Jorge Salazar-VegaMarco Coral-Almeida
Oct 11, 2020·International Journal of Environmental Research and Public Health·Sida LiuZhe Huang

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