A link between hypercholesterolemia and chronic lymphocytic leukemia

Leukemia & Lymphoma
Signy ChowDavid E Spaner

Abstract

The incidence of hypercholesterolemia and its possible relationship with clinical course were determined by reviewing the records of 231 consecutive patients presenting to a specialized Chronic Lymphocytic Leukemia (CLL) clinic. Evidence for elevated cholesterol was found in up to 174/231 patients (75%) based on existing use of statins (107 patients) or non-fasting low-density lipoprotein cholesterol levels greater than 2.5 mM. Excluding patients with 17p deletions, time to first treatment (TFT) was prolonged if patients were taking cholesterol-lowering statins (57.5 (IQR = 32, 77) vs 36 (IQR = 11, 100) months, p < 0.02). If patients were prescribed statins after being diagnosed with CLL, TFT was longer than if they were taking statins before the diagnosis. These observations suggest there is a high incidence of hypercholesterolemia in CLL patients and cholesterol-lowering may impact the disease course.

References

Jan 3, 2001·The New England Journal of Medicine·H DöhnerP Lichter
May 3, 2002·British Journal of Cancer·J A KayeH Jick
Dec 17, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Grzegorz S NowakowskiJames R Cerhan
Oct 12, 2010·Leukemia & Lymphoma·Daphne R FriedmanJ Brice Weinberg
Mar 23, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cari M KitaharaJonathan M Samet
Jun 3, 2011·The Journal of Clinical Investigation·Carey N Lumeng, Alan R Saltiel
Aug 4, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael B Fessler, John S Parks
Feb 1, 2012·Leukemia·S Tung, D E Spaner
Nov 9, 2012·The New England Journal of Medicine·Sune F NielsenStig E Bojesen
Nov 14, 2012·Archives of Internal Medicine·Davinder Sidhu, Christopher Naugler
Nov 20, 2012·Leukemia·D E SpanerR Gorzcynski
Apr 20, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P P Singh, S Singh
Aug 28, 2013·The Journal of Experimental Medicine·Autumn G York, Steven J Bensinger
Nov 28, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lorelei A Mucci, Meir J Stampfer
Jan 15, 2014·Leukemia·M MasoodiD E Spaner
Mar 25, 2014·Haematologica·Daniel CatovskyMonica Else
Jul 1, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P P Singh, S Singh

❮ Previous
Next ❯

Citations

Oct 22, 2016·Journal of the National Cancer Institute·Lee MozessohnRena Buckstein
Mar 9, 2017·The Journal of Pharmacy and Pharmacology·Sally SafwatNahed D Mortada
Nov 5, 2019·Genes & Development·Marissa Rashkovan, Adolfo Ferrando
Dec 6, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daniel Prieto, Pablo Oppezzo
Mar 23, 2021·Translational Oncology·Shyamananda Singh MayengbamManoj Kumar Bhat
Jun 1, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Khadijeh MahboobniaAmirhossein Sahebkar
Aug 18, 2021·British Journal of Haematology·Liam SmythMatthew C Cheung

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

CNS Lymphoma

In CNS lymphoma, cancerous cells from lymph tissues or other parts of the body form tumors in the brain and/or spinal cord. Here is the latest research on this rare non-Hodgkin lymphoma.

© 2021 Meta ULC. All rights reserved