A Link Between Hypoglycemia and Progression of Atherosclerosis in the Veterans Affairs Diabetes Trial (VADT)

Diabetes Care
Aramesh SaremiVeterans Affairs Diabetes Trial (VADT)

Abstract

To determine whether a link exists between serious hypoglycemia and progression of atherosclerosis in a substudy of the Veterans Affairs Diabetes Trial (VADT) and to examine whether glycemic control during the VADT modified the association between serious hypoglycemia and coronary artery calcium (CAC) progression. Serious hypoglycemia was defined as severe episodes with loss of consciousness or requiring assistance or documented glucose <50 mg/dL. Progression of CAC was determined in 197 participants with baseline and follow-up computed tomography scans. During an average follow-up of 4.5 years between scans, 97 participants reported severe hypoglycemia (n = 23) or glucose <50 mg/dL (n = 74). Serious hypoglycemia occurred more frequently in the intensive therapy group than in the standard treatment group (74% vs. 21%, P < 0.01). Serious hypoglycemia was not associated with progression of CAC in the entire cohort, but the interaction between serious hypoglycemia and treatment was significant (P < 0.01). Participants with serious hypoglycemia in the standard therapy group, but not in the intensive therapy group, had ∼50% greater progression of CAC than those without serious hypoglycemia (median 11.15 vs. 5.4 mm(3), P = 0.02). Adj...Continue Reading

References

Oct 30, 2003·Journal of Diabetes and Its Complications·Carlos AbrairaUNKNOWN VA Cooperative Study of Glycemic Control and Complications in Diabetes Mellitus Type 2
Apr 28, 2004·Diabetes Care·Peter D ReavenUNKNOWN Investigators for the Veterans Affairs Cooperative Study of Glycemic Control and Complications in Diabetes Mellitus Type 2
Apr 28, 2005·Diabetes Care·UNKNOWN Workgroup on Hypoglycemia, American Diabetes Association
Dec 24, 2005·The New England Journal of Medicine·David M NathanUNKNOWN Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Research
Feb 3, 2006·Diabetes/metabolism Research and Reviews·Ludovica PiconiAntonio Ceriello
Apr 13, 2006·JAMA : the Journal of the American Medical Association·Louis MonnierClaude Colette
Apr 4, 2007·The Journal of Clinical Investigation·Philip E Cryer
May 8, 2008·Diabetes/metabolism Research and Reviews·Rohana J Wright, Brian M Frier
Jun 10, 2008·The New England Journal of Medicine·Anushka PatelFlorence Travert
Dec 19, 2008·The New England Journal of Medicine·William DuckworthUNKNOWN VADT Investigators
May 29, 2010·Diabetes Care·Cyrus V DesouzaVivian Fonseca
Sep 3, 2010·Diabetes Care·Aramesh SaremiUNKNOWN Veterans Affairs Diabetes Trial (VADT)
Oct 12, 2010·The New England Journal of Medicine·Sophia ZoungasUNKNOWN ADVANCE Collaborative Group
Dec 20, 2011·Diabetes Care·Elizabeth R SeaquistUNKNOWN ACCORD Investigators
Jun 4, 2015·The New England Journal of Medicine·Rodney A HaywardUNKNOWN VADT Investigators

❮ Previous
Next ❯

Citations

Jun 9, 2016·MMW Fortschritte der Medizin·Werner Kern
Jun 28, 2016·Journal of Diabetes and Its Complications·Joseph G TimmonsGregory C Jones
Aug 8, 2018·Diabetes Care·Jin J ZhouUNKNOWN VADT Investigators
Nov 21, 2018·Diabetes Care·Stephen N DavisUNKNOWN Investigators of the Veterans Affairs Diabetes Trial
Apr 16, 2019·Journal of Diabetes·Brianna Johnson-Rabbett, Elizabeth R Seaquist
May 23, 2020·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Kamlesh KhuntiAslam Amod
Sep 30, 2016·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Elizabeth LowdenMark E Molitch
Nov 8, 2017·Expert Review of Endocrinology & Metabolism·Ian Charles DavisStephen N Davis
Jul 24, 2021·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Laura E FischerUNKNOWN LABS Investigators

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.