PMID: 11902125Mar 21, 2002Paper

A link between maze learning and hippocampal expression of neuroleukin and its receptor gp78

Journal of Neurochemistry
Yongquan LuoNan-Ping Weng

Abstract

Neuroleukin (NLK) is a multifunctional protein involved in neuronal growth and survival, cell motility and differentiation, and glucose metabolism. We report herein that hippocampal expression of NLK and its receptor gp78 is associated with maze learning in rats. First, mRNA levels of NLK and gp78 were significantly increased in hippocampi of male Fischer-344 rats following training in the Stone T-maze and the Morris water maze. Second, a parallel increase was found in hippocampal NLK and gp78 proteins after maze learning. Third, NLK and gp78 mRNA and protein expression in hippocampus was reduced in a group of aged rats that showed more errors during the acquisition of the Stone maze task as compared with young rats. Finally, application of recombinant NLK to hippocampal neurons significantly enhanced glutamate-induced ion currents, functional molecular changes that have been correlated with learning in vivo. Taken together, our results identify a novel association of hippocampal expression of NLK and its receptor gp78 with rat maze learning. Interaction of NLK with gp78 and subsequent signaling may strengthen synaptic mechanisms underlying learning and memory formation.

Citations

Aug 25, 2004·Neurotoxicity Research·Lionel Muller IgazJorge H Medina
Jan 30, 2008·Stem Cells and Development·Anita BhattacharyyaClive N Svendsen
Feb 3, 2005·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Arayo Haga
Mar 17, 2004·Genetics·Jennifer K Inlow, Linda L Restifo
May 9, 2003·Proceedings of the National Academy of Sciences of the United States of America·Mikhail ProsniakD Craig Hooper
Jul 30, 2005·Brain Research. Developmental Brain Research·Boris DecourtAziz Hafidi
Aug 7, 2002·FEBS Letters·Mohammad Amraei, Ivan R Nabi
Jul 16, 2003·Hypertension·Richard N Re
Sep 12, 2017·Frontiers in Cellular Neuroscience·Vibhuti JoshiAmit Mishra
Jun 4, 2019·Frontiers in Physiology·Mafalda Escobar-Henriques, Mariana Joaquim

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