PMID: 7906587Dec 1, 1993Paper

A linkage map of human chromosome 15 with an average resolution of 2 cM and containing 55 polymorphic microsatellites

Human Molecular Genetics
J S BeckmannA M Bowcock

Abstract

We have constructed a 2.0 centiMorgan (cM) resolution genetic linkage map for chromosome 15q that contains 55 polymorphic satellites and 3 RFLPs that have placed on the map with odds for order of at least 1,000:1. Genotypes from 67 polymorphic loci (64 polymorphic microsatellites) were used to construct the map. Nine genes are included in the 1,000:1 map and 37 markers have heterozygosities of at least 70%. The sex-equal map length is 128 cM and the largest genetic interval is 11 cM (15.5 cM on the female map). The female and male map lengths are 150 cM and 106 cM, respectively. The map was constructed with 'MultiMap' and is based on the CEPH reference pedigrees and includes over 12,000 new genotypes. A sub-set of 12 markers spanning the length of the linkage map were genotyped in a somatic cell hybrid panel with breakpoints that divided 15q into five segments. Cytogenetic placement agreed with the linkage positions for each of the microsatellites tested with the exception of one (ACTC) which failed to give consistent results. Ten spontaneous new mutations were identified from a subset of 42 polymorphic microsatellites (out of a total of 20,420 transmissions), giving an apparent observed spontaneous mutation rate of 5 x 10(-4) ...Continue Reading

Citations

Nov 14, 2001·Schizophrenia Research·D L GarverB Barnes
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·J GermanN A Ellis
Jul 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·D R DunbarI J Holt
May 13, 2010·BMC Medical Genetics·Simon C RamsdenKarin Buiting
Mar 1, 1996·Human Genetics·J BeutenP J Willems
Mar 10, 2009·Schizophrenia Research·Sarah E BergenKenneth S Kendler
Mar 31, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·N HateboerD Ravine
Jun 13, 1998·American Journal of Human Genetics·A E WandstratS Schwartz
Mar 24, 1999·Biological Psychiatry·R FreedmanS Leonard
Oct 14, 2004·Journal of Biochemistry and Molecular Biology·Daniel BorelinaIrene Szijan
Mar 27, 2002·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·N KatsumataT Tanaka
Aug 5, 2000·American Journal of Medical Genetics·E OlanderE A Wulfsberg
Aug 4, 1999·Brain : a Journal of Neurology·K M Bushby
Dec 30, 1996·American Journal of Medical Genetics·V TonkG N Wilson
Mar 1, 1996·American Journal of Medical Genetics·P K RoganM G Butler
Jan 2, 1995·American Journal of Medical Genetics·E BlennowM Nordenskjöld
Apr 1, 1996·Prenatal Diagnosis·S L ChristianD H Ledbetter
Jan 1, 1996·Human Molecular Genetics·N A Ellis, J German
Apr 23, 2008·Current Protocols in Human Genetics·J Hall, E Nanthakumar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.