PMID: 2857592Feb 15, 1985Paper

A linkage study of multiple endocrine neoplasia type IIa

Cancer Genetics and Cytogenetics
R E FerrellN A Samaan


Members of four families segregating for multiple endocrine neoplasia type IIa (Sipple's syndrome) were typed for 16 segregating blood group, erythrocyte enzyme, and plasma protein loci. Linkage analysis failed to find evidence favoring linkage between the multiple endocrine neoplasia mutation and any segregating marker. The data from this study were combined with the published data to rule out linkage for the HLA, ABO, Rh, or MNS loci at theta less than or equal to 0.25, the ADA, PGMI, AcP, GLOI, or GM loci at theta less than or equal to 0.10, and for GPT, PGD, or HpA at theta less than or equal to 0.05. The pooled data are inconclusive with respect to the previously suggested linkage to the P blood group locus.


May 17, 1996·American Journal of Medical Genetics·R E BrennerP Bartmann
Jul 1, 1995·Baillière's Clinical Endocrinology and Metabolism·G J CoteR F Gagel
Oct 1, 1995·Journal of Internal Medicine·F RaueB Niederle
Oct 1, 1992·Acta Paediatrica Japonica; Overseas Edition·S KuwashimaM Fujioka
Dec 1, 1988·Journal of Neurology, Neurosurgery, and Psychiatry·N L RosenbergN R Buist

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