A lipase fusion feasts on fat.

The Journal of Biological Chemistry
Philip M M Ruppert, Sander Kersten

Abstract

The enzyme lipoprotein lipase (LPL) is responsible for breaking down triglycerides in the blood. Mutations in LPL cause a rare but debilitating disorder characterized by excessive plasma triglyceride levels for which treatment options are limited. Nimonkar et al. now present a fusion protein between LPL and its physiological transporter GBIHBP1 that is highly active and largely resistant to physiological inhibitors of LPL. Injecting this fusion protein effectively lowers plasma triglycerides in mice and represents a promising new approach for lowering triglycerides in patients with familial chylomicronemia syndrome.

References

Dec 17, 2002·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·James R MeadDipak P Ramji
Apr 12, 2014·Biochimica Et Biophysica Acta·Sander Kersten
Mar 10, 2015·Nature Biotechnology·Chris Morrison
Mar 10, 2019·Proceedings of the National Academy of Sciences of the United States of America·Anne P BeigneuxStephen G Young
May 11, 2019·Proceedings of the National Academy of Sciences of the United States of America·Rishi AroraJohn W Trauger

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Citations

Nov 17, 2020·Frontiers in Endocrinology·Ronald B Goldberg, Alan Chait

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