PMID: 9182757May 30, 1997Paper

A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

Cell
H KouharaJ Schlessinger

Abstract

Activation of the Ras/MAPK signaling cascade is essential for growth factor-induced cell proliferation and differentiation. In this report, we describe the purification, cloning, and characterization of a novel protein, designated FRS2, that is tyrosine phosphorylated and binds to Grb2/Sos in response to FGF or NGF stimulation. We find that FRS2 is myristylated and that this modification is essential for membrane localization, tyrosine phosphorylation, Grb2/Sos recruitment, and MAPK activation. FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation. Finally, we demonstrate that FRS2 is closely related and probably indentical to SNT, the long-sought target of FGF and NGF receptors.

References

Jan 1, 1992·Advances in Cancer Research·C Basilico, D Moscatelli
Aug 1, 1994·Molecular and Cellular Biology·A G BatzerJ Schlessinger
Dec 16, 1994·Science·W M Kavanaugh, L T Williams
May 1, 1995·Trends in Biochemical Sciences·G MilliganA I Magee
Feb 1, 1994·Current Opinion in Genetics & Development·J Schlessinger
Jul 1, 1993·Current Biology : CB·T Pawson, J Schlessingert

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Citations

Jun 26, 1999·Microscopy Research and Technique·L J Klesse, L F Parada
Feb 19, 2000·Journal of Neuroscience Research·H YanoM V Chao
Jan 9, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·T J PooleC M Cox
Dec 18, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·C Z BorlandM J Stern
Feb 12, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Keiko AkagiIra O Daar
Apr 12, 2011·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Jennifer A CalvertKaren P Steel
Aug 1, 2013·Apoptosis : an International Journal on Programmed Cell Death·Kai Hung TiongChee-Onn Leong
Jan 31, 2004·Biochemical and Biophysical Research Communications·Satoshi YamadaAkihiko Yoshimura
Jan 8, 2004·Cellular Signalling·Peter KlintLena Claesson-Welsh
May 3, 2005·Cytokine & Growth Factor Reviews·Lisa DaileyClaudio Basilico
Feb 26, 2004·Experimental Cell Research·Dengshun MiaoJanet E Henderson
Nov 5, 2003·Experimental Cell Research·Emma RennelPär Gerwins
Mar 26, 2002·FEBS Letters·Kelley S YanMing Ming Zhou
May 17, 2000·Pharmaceutica acta Helvetiae·H Yano, M V Chao
Aug 1, 2000·Brain Research. Developmental Brain Research·R D LearishM Haak-Frendscho
Apr 3, 2001·Trends in Pharmacological Sciences·M J Cross, L Claesson-Welsh
Nov 26, 1998·Trends in Neurosciences·E Cattaneo, P G Pelicci
Mar 24, 1999·Trends in Neurosciences·P C OrbanR Brambilla
Mar 21, 2001·Cellular Signalling·K CailliauJ P Vilain
Dec 19, 2001·Cellular Signalling·Graeme R GuyEsther Sook Miin Wong
Jun 14, 2000·Current Opinion in Neurobiology·D R Kaplan, F D Miller
Oct 9, 2002·Current Opinion in Neurobiology·Gustavo Paratcha, Carlos F Ibáñez
Apr 8, 2000·Trends in Cell Biology·B N KholodenkoH V Westerhoff
Nov 24, 2001·Trends in Cell Biology·T PawsonP Nash
Aug 26, 1999·Trends in Endocrinology and Metabolism : TEM·B Margolis
Feb 14, 2013·Nature Reviews. Molecular Cell Biology·Regina Goetz, Moosa Mohammadi
Nov 26, 2003·Immunology and Cell Biology·Victor M ByrdGeraldine G Miller
Mar 22, 2002·Cellular Microbiology·Peggy J Rooney, Bruce S Klein

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