A literature review of the evidence that a 12% improvement in FEV1 is an appropriate cut-off for children

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
Russell J Hopp, Muhammad A Pasha

Abstract

A well-performed spirometry, using a change in forced expiratory volume in one second (FEV(1)) after albuterol, is commonly used to support the likelihood of an asthma diagnosis. The current standard, accepted by the 2007 National Heart Lung and Blood Institute Asthma Expert Panel Report-3 (EPR-3) guidelines, is a 12% improvement in the FEV(1) after a bronchodilator. We sought to determine whether existing studies support or refute using a 12% improvement as a significant change in FEV(1) in children and adolescents. We reviewed the literature of children and adolescents using Medline searches to discover pertinent population studies and comparative studies that included FEV(1) measurements. The majority of the discovered studies suggest a less stringent improvement in FEV(1) in children might be applicable. Supported by the published literature, we suggest an alternative interpretive strategy of expressing the results of a spirometry measurement when a diagnosis of asthma in a child is being considered using a bronchodilator response.

References

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Citations

Nov 23, 2018·The European Respiratory Journal·Leena E TuomistoHannu Kankaanranta
Nov 27, 2020·Clinical Reviews in Allergy & Immunology·Russell J HoppM Asghar Pasha
Apr 6, 2021·ERJ Open Research·Eero LauhkonenRichard Iles
Jun 11, 2021·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Russell J HoppM Asghar Pasha
Sep 14, 2021·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Maria Angela ToscaUNKNOWN ; the “ControL’Asma” Study Group

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